The development in rating-based executive functions in children at familial high risk of schizophrenia or bipolar disorder from age 7 to age 11: the Danish high risk and resilience study
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The development in rating-based executive functions in children at familial high risk of schizophrenia or bipolar disorder from age 7 to age 11 : the Danish high risk and resilience study. / Andreassen, Anna Krogh; Lambek, Rikke; Greve, Aja; Hemager, Nicoline; Knudsen, Christina Bruun; Veddum, Lotte; Birk, Merete; Søndergaard, Anne; Brandt, Julie Marie; Gregersen, Maja; Falkenberg-Krantz, Mette; Spang, Katrine Søborg; Ohland, Jessica; Burton, Birgitte Klee; Jepsen, Jens Richardt Møllegaard; Thorup, Anne Amalie Elgaard; Nordentoft, Merete; Mors, Ole; Bliksted, Vibeke Fuglsang.
In: European Child and Adolescent Psychiatry, Vol. 33, 2024, p. 549–560.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The development in rating-based executive functions in children at familial high risk of schizophrenia or bipolar disorder from age 7 to age 11
T2 - the Danish high risk and resilience study
AU - Andreassen, Anna Krogh
AU - Lambek, Rikke
AU - Greve, Aja
AU - Hemager, Nicoline
AU - Knudsen, Christina Bruun
AU - Veddum, Lotte
AU - Birk, Merete
AU - Søndergaard, Anne
AU - Brandt, Julie Marie
AU - Gregersen, Maja
AU - Falkenberg-Krantz, Mette
AU - Spang, Katrine Søborg
AU - Ohland, Jessica
AU - Burton, Birgitte Klee
AU - Jepsen, Jens Richardt Møllegaard
AU - Thorup, Anne Amalie Elgaard
AU - Nordentoft, Merete
AU - Mors, Ole
AU - Bliksted, Vibeke Fuglsang
N1 - Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
PY - 2024
Y1 - 2024
N2 - Executive functions (EF) deficits are well documented in children at familial high risk of schizophrenia (FHR-SZ), and to a lesser degree in children at familial high risk of bipolar disorder (FHR-BP). The aim of this study was to assess EF development in preadolescent children at FHR-SZ, FHR-BP and population-based controls (PBC) using a multi-informant rating scale. A total of 519 children (FHR-SZ, n = 201; FHR-BP, n = 119; PBC, n = 199) participated at age 7, at age 11 or at both time points. Caregivers and teachers completed the Behavior Rating Inventory of Executive Functions (BRIEF). The developmental pattern from age 7 to age 11, did not differ between groups. At age 11, caregivers and teachers rated children at FHR-SZ as having widespread EF deficits. A higher proportion of children at FHR-SZ had clinically significant scores on the General executive composite (GEC) and all BRIEF indices compared to PBC. According to the caregivers, children at FHR-BP had significantly more EF deficits than PBC on 9 out of 13 BRIEF scales, whereas according to teachers, they only had significantly more deficits on one subdomain (Initiate). Likewise, caregivers rated a significantly higher proportion of children at FHR-BP above the clinical cut-off on the GEC and Metacognition index, compared to PBC, whereas there were no significant differences according to teachers. This study highlights the relevance of including multi-informant rating scales in the assessment of EF in children at FHR-SZ and FHR-BP. The results imply a need to identify children at high risk who would benefit from targeted intervention.
AB - Executive functions (EF) deficits are well documented in children at familial high risk of schizophrenia (FHR-SZ), and to a lesser degree in children at familial high risk of bipolar disorder (FHR-BP). The aim of this study was to assess EF development in preadolescent children at FHR-SZ, FHR-BP and population-based controls (PBC) using a multi-informant rating scale. A total of 519 children (FHR-SZ, n = 201; FHR-BP, n = 119; PBC, n = 199) participated at age 7, at age 11 or at both time points. Caregivers and teachers completed the Behavior Rating Inventory of Executive Functions (BRIEF). The developmental pattern from age 7 to age 11, did not differ between groups. At age 11, caregivers and teachers rated children at FHR-SZ as having widespread EF deficits. A higher proportion of children at FHR-SZ had clinically significant scores on the General executive composite (GEC) and all BRIEF indices compared to PBC. According to the caregivers, children at FHR-BP had significantly more EF deficits than PBC on 9 out of 13 BRIEF scales, whereas according to teachers, they only had significantly more deficits on one subdomain (Initiate). Likewise, caregivers rated a significantly higher proportion of children at FHR-BP above the clinical cut-off on the GEC and Metacognition index, compared to PBC, whereas there were no significant differences according to teachers. This study highlights the relevance of including multi-informant rating scales in the assessment of EF in children at FHR-SZ and FHR-BP. The results imply a need to identify children at high risk who would benefit from targeted intervention.
KW - Bipolar disorder
KW - BRIEF
KW - Development
KW - Executive functions
KW - Rating-based assessment
KW - Schizophrenia
U2 - 10.1007/s00787-023-02177-w
DO - 10.1007/s00787-023-02177-w
M3 - Journal article
C2 - 36881155
AN - SCOPUS:85149407537
VL - 33
SP - 549
EP - 560
JO - European Child and Adolescent Psychiatry, Supplement
JF - European Child and Adolescent Psychiatry, Supplement
SN - 1433-5719
ER -
ID: 366645059