The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)
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The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review). / Carlsen Melander, Eva Maria; Jürgensen, Henrik J; Madsen, Daniel H; Engelholm, Lars H; Behrendt, Niels.
In: International Journal of Oncology, Vol. 47, No. 4, 10.2015, p. 1177-88.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)
AU - Carlsen Melander, Eva Maria
AU - Jürgensen, Henrik J
AU - Madsen, Daniel H
AU - Engelholm, Lars H
AU - Behrendt, Niels
PY - 2015/10
Y1 - 2015/10
N2 - The collagen receptor uPARAP/Endo180, the product of the MRC2 gene, is a central component in the collagen turnover process governed by various mesenchymal cells. Through the endocytosis of collagen or large collagen fragments, this recycling receptor serves to direct basement membrane collagen as well as interstitial collagen to lysosomal degradation. This capacity, shared only with the mannose receptor from the same protein family, endows uPARAP/Endo180 with a critical role in development and homeostasis, as well as in pathological disruptions of the extracellular matrix structure. Important pathological functions of uPARAP/Endo180 have been identified in various cancers and in several fibrotic conditions. With a particular focus on matrix turnover in cancer, this review presents the necessary background for understanding the function of uPARAP/Endo180 at the molecular and cellular level, followed by an in-depth survey of the available knowledge of the expression and role of this receptor in various types of cancer and other degenerative diseases.
AB - The collagen receptor uPARAP/Endo180, the product of the MRC2 gene, is a central component in the collagen turnover process governed by various mesenchymal cells. Through the endocytosis of collagen or large collagen fragments, this recycling receptor serves to direct basement membrane collagen as well as interstitial collagen to lysosomal degradation. This capacity, shared only with the mannose receptor from the same protein family, endows uPARAP/Endo180 with a critical role in development and homeostasis, as well as in pathological disruptions of the extracellular matrix structure. Important pathological functions of uPARAP/Endo180 have been identified in various cancers and in several fibrotic conditions. With a particular focus on matrix turnover in cancer, this review presents the necessary background for understanding the function of uPARAP/Endo180 at the molecular and cellular level, followed by an in-depth survey of the available knowledge of the expression and role of this receptor in various types of cancer and other degenerative diseases.
KW - Animals
KW - Collagen
KW - Extracellular Matrix
KW - Humans
KW - Neoplasms
KW - Receptors, Mitogen
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
KW - Review
U2 - 10.3892/ijo.2015.3120
DO - 10.3892/ijo.2015.3120
M3 - Journal article
C2 - 26316068
VL - 47
SP - 1177
EP - 1188
JO - International Journal of Oncology
JF - International Journal of Oncology
SN - 1019-6439
IS - 4
ER -
ID: 169565690