The clinical value of faecal bile acid determination in patients with chronic diarrhoea of unknown origin
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The clinical value of faecal bile acid determination in patients with chronic diarrhoea of unknown origin. / Otte, J. J.; Andersen, J. R.
In: Scandinavian Journal of Gastroenterology, Vol. 21, No. 5, 1986, p. 585-588.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The clinical value of faecal bile acid determination in patients with chronic diarrhoea of unknown origin
AU - Otte, J. J.
AU - Andersen, J. R.
PY - 1986
Y1 - 1986
N2 - To evaluate the diagnostic value of faecal total bile acid determination in adult patients with chronic diarrhoea, output and concentration of 3a-hydroxy-bile acids were determined in 28 patients. The patients had normal results of primary biochemical, radiologic, and endoscopic examinations. Stools were sampled for 3 days while on a standardized diet. The patients were observed until final diagnosis was obtained; Crohn's disease was diagnosed in 5 cases, osmotic diarrhoea in 4, bacterial overgrowth in 3, laxative abuse in 2, other specific causes in 3, and persisting lack of specific diagnosis in 11. No difference in output or concentration of faecal bile acids was found between the groups. Six patients with high bile acid outputs benefited from treatment with cholestyramine. Accordingly, determination of total bile acids in stools cannot be recommended as a primary test in patients with chronic diarrhoea.
AB - To evaluate the diagnostic value of faecal total bile acid determination in adult patients with chronic diarrhoea, output and concentration of 3a-hydroxy-bile acids were determined in 28 patients. The patients had normal results of primary biochemical, radiologic, and endoscopic examinations. Stools were sampled for 3 days while on a standardized diet. The patients were observed until final diagnosis was obtained; Crohn's disease was diagnosed in 5 cases, osmotic diarrhoea in 4, bacterial overgrowth in 3, laxative abuse in 2, other specific causes in 3, and persisting lack of specific diagnosis in 11. No difference in output or concentration of faecal bile acids was found between the groups. Six patients with high bile acid outputs benefited from treatment with cholestyramine. Accordingly, determination of total bile acids in stools cannot be recommended as a primary test in patients with chronic diarrhoea.
KW - Bile acid metabolism
KW - Crohn's disease
KW - Diarrhoea diagnosis
U2 - 10.3109/00365528609003104
DO - 10.3109/00365528609003104
M3 - Journal article
C2 - 3749797
AN - SCOPUS:0022508747
VL - 21
SP - 585
EP - 588
JO - Scandinavian Journal of Gastroenterology. Supplement
JF - Scandinavian Journal of Gastroenterology. Supplement
SN - 0085-5928
IS - 5
ER -
ID: 251992791