The Cellular Response to Transcription-Blocking DNA Damage

Forskning

The Cellular Response to Transcription-Blocking DNA Damage

Research output: Contribution to journal › Review › Research › peer-review

Standard

The Cellular Response to Transcription-Blocking DNA Damage. / Gregersen, Lea H; Svejstrup, Jesper Q.

In: Trends in Biochemical Sciences, Vol. 43, No. 5, 2018, p. 327-341.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Gregersen, LH & Svejstrup, JQ 2018, 'The Cellular Response to Transcription-Blocking DNA Damage', Trends in Biochemical Sciences, vol. 43, no. 5, pp. 327-341. https://doi.org/10.1016/j.tibs.2018.02.010

APA

Gregersen, L. H., & Svejstrup, J. Q. (2018). The Cellular Response to Transcription-Blocking DNA Damage. Trends in Biochemical Sciences, 43(5), 327-341. https://doi.org/10.1016/j.tibs.2018.02.010

Vancouver

Gregersen LH, Svejstrup JQ. The Cellular Response to Transcription-Blocking DNA Damage. Trends in Biochemical Sciences. 2018;43(5):327-341. https://doi.org/10.1016/j.tibs.2018.02.010

Author

Gregersen, Lea H ; Svejstrup, Jesper Q. / The Cellular Response to Transcription-Blocking DNA Damage. In: Trends in Biochemical Sciences. 2018 ; Vol. 43, No. 5. pp. 327-341.

Bibtex

@article{fe347acbb0ca4b42bb9b7d38d5d0b12d,

title = "The Cellular Response to Transcription-Blocking DNA Damage",

abstract = "In response to transcription-blocking DNA lesions such as those generated by UV irradiation, cells activate a multipronged DNA damage response. This response encompasses repair of the lesions that stall RNA polymerase (RNAP) but also a poorly understood, genome-wide shutdown of transcription, even of genes that are not damaged. Over the past few years, a number of new results have shed light on this intriguing DNA damage response at the structural, biochemical, cell biological, and systems biology level. In this review we summarize the most important findings.",

keywords = "Animals, DNA Damage, DNA Repair, Humans, Nucleotides/genetics, Transcription, Genetic/genetics",

author = "Gregersen, {Lea H} and Svejstrup, {Jesper Q}",

year = "2018",

doi = "10.1016/j.tibs.2018.02.010",

language = "English",

volume = "43",

pages = "327--341",

journal = "Trends in Biochemical Sciences",

issn = "0968-0004",

publisher = "Elsevier",

number = "5",

}

RIS

TY - JOUR

T1 - The Cellular Response to Transcription-Blocking DNA Damage

AU - Gregersen, Lea H

AU - Svejstrup, Jesper Q

PY - 2018

Y1 - 2018

N2 - In response to transcription-blocking DNA lesions such as those generated by UV irradiation, cells activate a multipronged DNA damage response. This response encompasses repair of the lesions that stall RNA polymerase (RNAP) but also a poorly understood, genome-wide shutdown of transcription, even of genes that are not damaged. Over the past few years, a number of new results have shed light on this intriguing DNA damage response at the structural, biochemical, cell biological, and systems biology level. In this review we summarize the most important findings.

AB - In response to transcription-blocking DNA lesions such as those generated by UV irradiation, cells activate a multipronged DNA damage response. This response encompasses repair of the lesions that stall RNA polymerase (RNAP) but also a poorly understood, genome-wide shutdown of transcription, even of genes that are not damaged. Over the past few years, a number of new results have shed light on this intriguing DNA damage response at the structural, biochemical, cell biological, and systems biology level. In this review we summarize the most important findings.

KW - Animals

KW - DNA Damage

KW - DNA Repair

KW - Humans

KW - Nucleotides/genetics

KW - Transcription, Genetic/genetics

U2 - 10.1016/j.tibs.2018.02.010

DO - 10.1016/j.tibs.2018.02.010

M3 - Review

C2 - 29699641

VL - 43

SP - 327

EP - 341

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0968-0004

IS - 5

ER -

ID: 328236460