The antiinflammatory moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The antiinflammatory moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger. / Ahnfelt-Rønne, I; Nielsen, O H.

In: Agents and Actions, Vol. 21, No. 1-2, 06.1987, p. 191-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ahnfelt-Rønne, I & Nielsen, OH 1987, 'The antiinflammatory moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger', Agents and Actions, vol. 21, no. 1-2, pp. 191-4.

APA

Ahnfelt-Rønne, I., & Nielsen, O. H. (1987). The antiinflammatory moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger. Agents and Actions, 21(1-2), 191-4.

Vancouver

Ahnfelt-Rønne I, Nielsen OH. The antiinflammatory moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger. Agents and Actions. 1987 Jun;21(1-2):191-4.

Author

Ahnfelt-Rønne, I ; Nielsen, O H. / The antiinflammatory moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger. In: Agents and Actions. 1987 ; Vol. 21, No. 1-2. pp. 191-4.

Bibtex

@article{1a173084c46441b3ad23df8e6c8c54d5,
title = "The antiinflammatory moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger",
abstract = "Using a novel spectrophotometric assay to detect free radical scavengers, the effects of sulfasalazine, a compound frequently administered in the treatment of chronic inflammatory bowel disease, and its main metabolites, 5-aminosalicylic acid (5-ASA), sulfapyridine, and N-acetyl-5-ASA, were compared with biological antioxidants (nordihydroguaiaretic acid (NDGA), alpha-tocopherol, and ascorbic acid) and antiinflammatory salicylates (acetylsalicylic acid and sodium salicylate). The results show that 5-ASA, but neither sulfasalazine and its other metabolites, nor the salicylates, shares with the biological antioxidants the property of being a potent scavenger of free radicals. Since 5-ASA is formed in millimolar concentrations in the colon of sulfasalazine-treated patients this mode of action may explain the beneficial effect of sulfasalazine in inflammatory bowel disease. Locally formed 5-ASA may break the free radical chain reaction initiated and maintained by activated phagocytes, thus arresting the perpetuating tissue destruction. This mechanism may indicate a general potential for radical scavengers in chronic inflammation.",
keywords = "Anti-Inflammatory Agents, Non-Steroidal/pharmacology, Antioxidants/pharmacology, Biphenyl Compounds, Free Radicals, Hydrazines/metabolism, Oxidation-Reduction, Picrates, Salicylates/pharmacology, Spectrophotometry, Sulfasalazine/metabolism",
author = "I Ahnfelt-R{\o}nne and Nielsen, {O H}",
year = "1987",
month = jun,
language = "English",
volume = "21",
pages = "191--4",
journal = "Agents and Actions",
issn = "0065-4299",
publisher = "Birkhauser Verlag Basel",
number = "1-2",

}

RIS

TY - JOUR

T1 - The antiinflammatory moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger

AU - Ahnfelt-Rønne, I

AU - Nielsen, O H

PY - 1987/6

Y1 - 1987/6

N2 - Using a novel spectrophotometric assay to detect free radical scavengers, the effects of sulfasalazine, a compound frequently administered in the treatment of chronic inflammatory bowel disease, and its main metabolites, 5-aminosalicylic acid (5-ASA), sulfapyridine, and N-acetyl-5-ASA, were compared with biological antioxidants (nordihydroguaiaretic acid (NDGA), alpha-tocopherol, and ascorbic acid) and antiinflammatory salicylates (acetylsalicylic acid and sodium salicylate). The results show that 5-ASA, but neither sulfasalazine and its other metabolites, nor the salicylates, shares with the biological antioxidants the property of being a potent scavenger of free radicals. Since 5-ASA is formed in millimolar concentrations in the colon of sulfasalazine-treated patients this mode of action may explain the beneficial effect of sulfasalazine in inflammatory bowel disease. Locally formed 5-ASA may break the free radical chain reaction initiated and maintained by activated phagocytes, thus arresting the perpetuating tissue destruction. This mechanism may indicate a general potential for radical scavengers in chronic inflammation.

AB - Using a novel spectrophotometric assay to detect free radical scavengers, the effects of sulfasalazine, a compound frequently administered in the treatment of chronic inflammatory bowel disease, and its main metabolites, 5-aminosalicylic acid (5-ASA), sulfapyridine, and N-acetyl-5-ASA, were compared with biological antioxidants (nordihydroguaiaretic acid (NDGA), alpha-tocopherol, and ascorbic acid) and antiinflammatory salicylates (acetylsalicylic acid and sodium salicylate). The results show that 5-ASA, but neither sulfasalazine and its other metabolites, nor the salicylates, shares with the biological antioxidants the property of being a potent scavenger of free radicals. Since 5-ASA is formed in millimolar concentrations in the colon of sulfasalazine-treated patients this mode of action may explain the beneficial effect of sulfasalazine in inflammatory bowel disease. Locally formed 5-ASA may break the free radical chain reaction initiated and maintained by activated phagocytes, thus arresting the perpetuating tissue destruction. This mechanism may indicate a general potential for radical scavengers in chronic inflammation.

KW - Anti-Inflammatory Agents, Non-Steroidal/pharmacology

KW - Antioxidants/pharmacology

KW - Biphenyl Compounds

KW - Free Radicals

KW - Hydrazines/metabolism

KW - Oxidation-Reduction

KW - Picrates

KW - Salicylates/pharmacology

KW - Spectrophotometry

KW - Sulfasalazine/metabolism

M3 - Journal article

C2 - 2888280

VL - 21

SP - 191

EP - 194

JO - Agents and Actions

JF - Agents and Actions

SN - 0065-4299

IS - 1-2

ER -

ID: 218730040