Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects
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Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects. / Sharpe, R.M.; Skakkebæk, Niels Erik.
In: Fertility and Sterility, Vol. 89, No. 2 Suppl, 2008, p. e33-e38.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects
AU - Sharpe, R.M.
AU - Skakkebæk, Niels Erik
PY - 2008
Y1 - 2008
N2 - Reproductive disorders of newborn (cryptorchidism, hypospadias) and young adult males (low sperm counts, testicular germ cell cancer) are common and/or increasing in incidence. It has been hypothesized that these disorders may comprise a testicular dysgenesis syndrome (TDS) with a common origin in fetal life. This has been supported by findings in an animal model of TDS involving fetal exposure to n(dibutyl) phthalate, as well as by new clinical studies. Recent advances in understanding from such studies have led to refinement of the TDS hypothesis, highlighting the central role that deficient androgen production/action during fetal testis development, may play in the origin of downstream disorders Udgivelsesdato: 2008/2
AB - Reproductive disorders of newborn (cryptorchidism, hypospadias) and young adult males (low sperm counts, testicular germ cell cancer) are common and/or increasing in incidence. It has been hypothesized that these disorders may comprise a testicular dysgenesis syndrome (TDS) with a common origin in fetal life. This has been supported by findings in an animal model of TDS involving fetal exposure to n(dibutyl) phthalate, as well as by new clinical studies. Recent advances in understanding from such studies have led to refinement of the TDS hypothesis, highlighting the central role that deficient androgen production/action during fetal testis development, may play in the origin of downstream disorders Udgivelsesdato: 2008/2
M3 - Journal article
VL - 89
SP - e33-e38
JO - Sexuality, Reproduction and Menopause
JF - Sexuality, Reproduction and Menopause
SN - 1546-2501
IS - 2 Suppl
ER -
ID: 14175290