Test for Informative Cluster Size With Right Censored Survival Data
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Test for Informative Cluster Size With Right Censored Survival Data. / Meddis, Alessandra; Latouche, Aurélien.
In: Statistica Sinica, Vol. 34, No. 1, 2024, p. 181-199.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Test for Informative Cluster Size With Right Censored Survival Data
AU - Meddis, Alessandra
AU - Latouche, Aurélien
N1 - Publisher Copyright: © 2024 Institute of Statistical Science. All rights reserved.
PY - 2024
Y1 - 2024
N2 - Clustered survival data often arise in biomedical research. When the outcome depends on the size of the cluster, the cluster size is said to be informative. Many studies assume a noninformative cluster size, even though it may not always be true. We propose a test for the assumption of informative cluster size in clustered survival data with right censoring. We use standard martingale results to obtain the asymptotic distribution of the test statistic. Simulation studies show that the proposed test works well under various scenarios. To illustrate the proposed approach, we consider several applications: periodontal data, a multicentric study of patients with liver disease, and a recent data set of patients with metastatic cancer treated using immunotherapy.
AB - Clustered survival data often arise in biomedical research. When the outcome depends on the size of the cluster, the cluster size is said to be informative. Many studies assume a noninformative cluster size, even though it may not always be true. We propose a test for the assumption of informative cluster size in clustered survival data with right censoring. We use standard martingale results to obtain the asymptotic distribution of the test statistic. Simulation studies show that the proposed test works well under various scenarios. To illustrate the proposed approach, we consider several applications: periodontal data, a multicentric study of patients with liver disease, and a recent data set of patients with metastatic cancer treated using immunotherapy.
KW - Clustered data
KW - hypothesis testing
KW - informative cluster size
KW - survival analysis
U2 - 10.5705/ss.202021.0349
DO - 10.5705/ss.202021.0349
M3 - Journal article
AN - SCOPUS:85183936667
VL - 34
SP - 181
EP - 199
JO - Statistica Sinica
JF - Statistica Sinica
SN - 1017-0405
IS - 1
ER -
ID: 389670543