Technetium 99m diphosphonate uptake and intraosseous hemodynamics during venous congestion in bone. Knee joint tamponade studied in immature dogs
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Technetium 99m diphosphonate uptake and intraosseous hemodynamics during venous congestion in bone. Knee joint tamponade studied in immature dogs. / Hansen, E S; Hjortdal, V E; Kjølseth, D; He, S Z; Høy, K; Søballe, K; Bünger, C.
In: Skeletal Radiology, Vol. 20, No. 3, 1991, p. 159-68.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Technetium 99m diphosphonate uptake and intraosseous hemodynamics during venous congestion in bone. Knee joint tamponade studied in immature dogs
AU - Hansen, E S
AU - Hjortdal, V E
AU - Kjølseth, D
AU - He, S Z
AU - Høy, K
AU - Søballe, K
AU - Bünger, C
PY - 1991
Y1 - 1991
N2 - Venous congestion in bone is a common early feature of inflammatory and degenerative joint diseases. An experimental study was performed of the relationship between the scintigraphic appearance of joints and the intraosseous hemodynamics during venous congestion caused by obstruction of the osseous venous drainage by increased intra-articular pressure. Intra-articular pressure was raised to 75% of mean arterial pressure in one knee each of 8 immature dogs. This caused elevated intraosseous pressure in the distal femoral epiphysis but not in the metaphysis. The elevated intraosseous pressure in the affected femoral epiphysis was associated with decreased technetium 99m diphosphonate uptake and blood flow, unaltered vascular volume and tissue hematocrit, and prolonged transit time of blood in the central cancellous bone. The decreased radionuclide uptake during intraosseous venous congestion thus appeared to reflect a decreased blood supply. However, by multiple regression analysis, the diphosphonate uptake in bone generally varied positively with blood flow and plasma volume and inversely with red cell volume in a nonlinear, multifactorial relationship.
AB - Venous congestion in bone is a common early feature of inflammatory and degenerative joint diseases. An experimental study was performed of the relationship between the scintigraphic appearance of joints and the intraosseous hemodynamics during venous congestion caused by obstruction of the osseous venous drainage by increased intra-articular pressure. Intra-articular pressure was raised to 75% of mean arterial pressure in one knee each of 8 immature dogs. This caused elevated intraosseous pressure in the distal femoral epiphysis but not in the metaphysis. The elevated intraosseous pressure in the affected femoral epiphysis was associated with decreased technetium 99m diphosphonate uptake and blood flow, unaltered vascular volume and tissue hematocrit, and prolonged transit time of blood in the central cancellous bone. The decreased radionuclide uptake during intraosseous venous congestion thus appeared to reflect a decreased blood supply. However, by multiple regression analysis, the diphosphonate uptake in bone generally varied positively with blood flow and plasma volume and inversely with red cell volume in a nonlinear, multifactorial relationship.
KW - Animals
KW - Bone and Bones/blood supply
KW - Diphosphonates
KW - Dogs
KW - Hindlimb
KW - Joint Diseases/diagnostic imaging
KW - Organotechnetium Compounds
KW - Radionuclide Imaging
KW - Regional Blood Flow/physiology
U2 - 10.1007/BF00241659
DO - 10.1007/BF00241659
M3 - Journal article
C2 - 2057786
VL - 20
SP - 159
EP - 168
JO - Skeletal Radiology
JF - Skeletal Radiology
SN - 0364-2348
IS - 3
ER -
ID: 244328538