Targeted delivery of alcohol-containing payloads with antibody-drug conjugates
Research output: Contribution to journal › Journal article › Research › peer-review
We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.
Original language | English |
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Journal | Chemical Communications |
Volume | 59 |
Issue number | 47 |
Pages (from-to) | 7240-7242 |
ISSN | 1359-7345 |
DOIs | |
Publication status | Published - 2023 |
ID: 347702706