Systemic treatment with epidermal growth factor in pigs induces ductal proliferations in the pancreas
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Systemic treatment with epidermal growth factor in pigs induces ductal proliferations in the pancreas. / Vinter-Jensen, Lars; Juhl, C O; Teglbjaerg, P S; Poulsen, Steen Seier; Dajani, E Z; Nexø, Ebba.
In: Gastroenterology, Vol. 113, No. 4, 10.1997, p. 1367-1374.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Systemic treatment with epidermal growth factor in pigs induces ductal proliferations in the pancreas
AU - Vinter-Jensen, Lars
AU - Juhl, C O
AU - Teglbjaerg, P S
AU - Poulsen, Steen Seier
AU - Dajani, E Z
AU - Nexø, Ebba
PY - 1997/10
Y1 - 1997/10
N2 - Epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and the EGF receptor are often overexpressed in chronic pancreatitis and in malignant pancreatic growth. Transgenic mice overexpressing TGF-alpha develop tissue changes in the pancrease resembling changes found in chronic pancreatitis. The effects of systemic treatment with EGF on the porcine pancrease were investigated in this study.
AB - Epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and the EGF receptor are often overexpressed in chronic pancreatitis and in malignant pancreatic growth. Transgenic mice overexpressing TGF-alpha develop tissue changes in the pancrease resembling changes found in chronic pancreatitis. The effects of systemic treatment with EGF on the porcine pancrease were investigated in this study.
KW - Animals
KW - Cell Division
KW - Cytoplasmic Granules
KW - Epidermal Growth Factor
KW - Epithelial Cells
KW - Epithelium
KW - Female
KW - Glycoconjugates
KW - Islets of Langerhans
KW - Male
KW - Mice
KW - Mice, Transgenic
KW - Mucins
KW - Pancreatic Ducts
KW - Pancreatic Polypeptide
KW - Proliferating Cell Nuclear Antigen
KW - Somatostatin
KW - Swine
KW - Swine, Miniature
M3 - Journal article
C2 - 9322532
VL - 113
SP - 1367
EP - 1374
JO - Gastroenterology
JF - Gastroenterology
SN - 0016-5085
IS - 4
ER -
ID: 226386