Synovitis reduced by inhibition of leukotriene B4. Carrageenan-induced gonarthritis studied in dogs

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Synovitis reduced by inhibition of leukotriene B4. Carrageenan-induced gonarthritis studied in dogs. / Hansen, E S; Fogh, Karsten; Hjortdal, V E; Henriksen, T B; Noer, I; Ewald, H; Herlin, T; Kragballe, K; Bünger, C.

In: Acta Orthopaedica Scandinavica, Vol. 61, No. 3, 06.1990, p. 207-12.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hansen, ES, Fogh, K, Hjortdal, VE, Henriksen, TB, Noer, I, Ewald, H, Herlin, T, Kragballe, K & Bünger, C 1990, 'Synovitis reduced by inhibition of leukotriene B4. Carrageenan-induced gonarthritis studied in dogs', Acta Orthopaedica Scandinavica, vol. 61, no. 3, pp. 207-12. https://doi.org/10.3109/17453679008993502

APA

Hansen, E. S., Fogh, K., Hjortdal, V. E., Henriksen, T. B., Noer, I., Ewald, H., Herlin, T., Kragballe, K., & Bünger, C. (1990). Synovitis reduced by inhibition of leukotriene B4. Carrageenan-induced gonarthritis studied in dogs. Acta Orthopaedica Scandinavica, 61(3), 207-12. https://doi.org/10.3109/17453679008993502

Vancouver

Hansen ES, Fogh K, Hjortdal VE, Henriksen TB, Noer I, Ewald H et al. Synovitis reduced by inhibition of leukotriene B4. Carrageenan-induced gonarthritis studied in dogs. Acta Orthopaedica Scandinavica. 1990 Jun;61(3):207-12. https://doi.org/10.3109/17453679008993502

Author

Hansen, E S ; Fogh, Karsten ; Hjortdal, V E ; Henriksen, T B ; Noer, I ; Ewald, H ; Herlin, T ; Kragballe, K ; Bünger, C. / Synovitis reduced by inhibition of leukotriene B4. Carrageenan-induced gonarthritis studied in dogs. In: Acta Orthopaedica Scandinavica. 1990 ; Vol. 61, No. 3. pp. 207-12.

Bibtex

@article{8818c623c9124da8b29fbb8f0b632bdc,
title = "Synovitis reduced by inhibition of leukotriene B4. Carrageenan-induced gonarthritis studied in dogs",
abstract = "The pathophysiologic significance of leukotriene B4 (LTB4) in arthritis was studied in dogs by unilateral intraarticular deposition of 15-hydroxy-eicosatetraenoic acid (15-HETE), an endogenous inhibitor of the formation and the effects of LTB4, in bilateral carrageenan-induced gonarthritis. LTB4 in synovial fluid was selectively inhibited in 15-HETE treated joints, the formation of prostaglandin E2 (PGE2) being largely unaffected. The clinical symptoms, intraarticular pressure, and extractable synovial fluid volume were reduced in treated joints. No effect could be discerned regarding blood flow in the synovial membrane, capsule, or juxta-articular bone as measured by tracer microspheres; and no effect on bone metabolism was found as judged by 99mTc-diphosphonate uptake. Thus, inhibition of LTB4 reduces joint exudation, but does not seem to interfere with changes in juxta-articular hemodynamics or bone metabolism following synovial inflammation.",
keywords = "Animals, Arthritis/chemically induced, Carrageenan, Dinoprostone/metabolism, Dogs, Hydroxyeicosatetraenoic Acids/pharmacology, Knee Joint, Leukotriene B4/antagonists & inhibitors, Pressure, Regional Blood Flow, Synovial Fluid/metabolism, Synovitis/chemically induced",
author = "Hansen, {E S} and Karsten Fogh and Hjortdal, {V E} and Henriksen, {T B} and I Noer and H Ewald and T Herlin and K Kragballe and C B{\"u}nger",
year = "1990",
month = jun,
doi = "10.3109/17453679008993502",
language = "English",
volume = "61",
pages = "207--12",
journal = "Acta Orthopaedica Scandinavica",
issn = "0001-6470",
publisher = "Taylor & Francis",
number = "3",

}

RIS

TY - JOUR

T1 - Synovitis reduced by inhibition of leukotriene B4. Carrageenan-induced gonarthritis studied in dogs

AU - Hansen, E S

AU - Fogh, Karsten

AU - Hjortdal, V E

AU - Henriksen, T B

AU - Noer, I

AU - Ewald, H

AU - Herlin, T

AU - Kragballe, K

AU - Bünger, C

PY - 1990/6

Y1 - 1990/6

N2 - The pathophysiologic significance of leukotriene B4 (LTB4) in arthritis was studied in dogs by unilateral intraarticular deposition of 15-hydroxy-eicosatetraenoic acid (15-HETE), an endogenous inhibitor of the formation and the effects of LTB4, in bilateral carrageenan-induced gonarthritis. LTB4 in synovial fluid was selectively inhibited in 15-HETE treated joints, the formation of prostaglandin E2 (PGE2) being largely unaffected. The clinical symptoms, intraarticular pressure, and extractable synovial fluid volume were reduced in treated joints. No effect could be discerned regarding blood flow in the synovial membrane, capsule, or juxta-articular bone as measured by tracer microspheres; and no effect on bone metabolism was found as judged by 99mTc-diphosphonate uptake. Thus, inhibition of LTB4 reduces joint exudation, but does not seem to interfere with changes in juxta-articular hemodynamics or bone metabolism following synovial inflammation.

AB - The pathophysiologic significance of leukotriene B4 (LTB4) in arthritis was studied in dogs by unilateral intraarticular deposition of 15-hydroxy-eicosatetraenoic acid (15-HETE), an endogenous inhibitor of the formation and the effects of LTB4, in bilateral carrageenan-induced gonarthritis. LTB4 in synovial fluid was selectively inhibited in 15-HETE treated joints, the formation of prostaglandin E2 (PGE2) being largely unaffected. The clinical symptoms, intraarticular pressure, and extractable synovial fluid volume were reduced in treated joints. No effect could be discerned regarding blood flow in the synovial membrane, capsule, or juxta-articular bone as measured by tracer microspheres; and no effect on bone metabolism was found as judged by 99mTc-diphosphonate uptake. Thus, inhibition of LTB4 reduces joint exudation, but does not seem to interfere with changes in juxta-articular hemodynamics or bone metabolism following synovial inflammation.

KW - Animals

KW - Arthritis/chemically induced

KW - Carrageenan

KW - Dinoprostone/metabolism

KW - Dogs

KW - Hydroxyeicosatetraenoic Acids/pharmacology

KW - Knee Joint

KW - Leukotriene B4/antagonists & inhibitors

KW - Pressure

KW - Regional Blood Flow

KW - Synovial Fluid/metabolism

KW - Synovitis/chemically induced

U2 - 10.3109/17453679008993502

DO - 10.3109/17453679008993502

M3 - Journal article

C2 - 2164743

VL - 61

SP - 207

EP - 212

JO - Acta Orthopaedica Scandinavica

JF - Acta Orthopaedica Scandinavica

SN - 0001-6470

IS - 3

ER -

ID: 244328902