Synovitis reduced by inhibition of leukotriene B4. Carrageenan-induced gonarthritis studied in dogs
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Synovitis reduced by inhibition of leukotriene B4. Carrageenan-induced gonarthritis studied in dogs. / Hansen, E S; Fogh, Karsten; Hjortdal, V E; Henriksen, T B; Noer, I; Ewald, H; Herlin, T; Kragballe, K; Bünger, C.
In: Acta Orthopaedica Scandinavica, Vol. 61, No. 3, 06.1990, p. 207-12.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Synovitis reduced by inhibition of leukotriene B4. Carrageenan-induced gonarthritis studied in dogs
AU - Hansen, E S
AU - Fogh, Karsten
AU - Hjortdal, V E
AU - Henriksen, T B
AU - Noer, I
AU - Ewald, H
AU - Herlin, T
AU - Kragballe, K
AU - Bünger, C
PY - 1990/6
Y1 - 1990/6
N2 - The pathophysiologic significance of leukotriene B4 (LTB4) in arthritis was studied in dogs by unilateral intraarticular deposition of 15-hydroxy-eicosatetraenoic acid (15-HETE), an endogenous inhibitor of the formation and the effects of LTB4, in bilateral carrageenan-induced gonarthritis. LTB4 in synovial fluid was selectively inhibited in 15-HETE treated joints, the formation of prostaglandin E2 (PGE2) being largely unaffected. The clinical symptoms, intraarticular pressure, and extractable synovial fluid volume were reduced in treated joints. No effect could be discerned regarding blood flow in the synovial membrane, capsule, or juxta-articular bone as measured by tracer microspheres; and no effect on bone metabolism was found as judged by 99mTc-diphosphonate uptake. Thus, inhibition of LTB4 reduces joint exudation, but does not seem to interfere with changes in juxta-articular hemodynamics or bone metabolism following synovial inflammation.
AB - The pathophysiologic significance of leukotriene B4 (LTB4) in arthritis was studied in dogs by unilateral intraarticular deposition of 15-hydroxy-eicosatetraenoic acid (15-HETE), an endogenous inhibitor of the formation and the effects of LTB4, in bilateral carrageenan-induced gonarthritis. LTB4 in synovial fluid was selectively inhibited in 15-HETE treated joints, the formation of prostaglandin E2 (PGE2) being largely unaffected. The clinical symptoms, intraarticular pressure, and extractable synovial fluid volume were reduced in treated joints. No effect could be discerned regarding blood flow in the synovial membrane, capsule, or juxta-articular bone as measured by tracer microspheres; and no effect on bone metabolism was found as judged by 99mTc-diphosphonate uptake. Thus, inhibition of LTB4 reduces joint exudation, but does not seem to interfere with changes in juxta-articular hemodynamics or bone metabolism following synovial inflammation.
KW - Animals
KW - Arthritis/chemically induced
KW - Carrageenan
KW - Dinoprostone/metabolism
KW - Dogs
KW - Hydroxyeicosatetraenoic Acids/pharmacology
KW - Knee Joint
KW - Leukotriene B4/antagonists & inhibitors
KW - Pressure
KW - Regional Blood Flow
KW - Synovial Fluid/metabolism
KW - Synovitis/chemically induced
U2 - 10.3109/17453679008993502
DO - 10.3109/17453679008993502
M3 - Journal article
C2 - 2164743
VL - 61
SP - 207
EP - 212
JO - Acta Orthopaedica Scandinavica
JF - Acta Orthopaedica Scandinavica
SN - 0001-6470
IS - 3
ER -
ID: 244328902