TY - JOUR

T1 - Surviving Sepsis Campaign

T2 - guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19)

AU - Alhazzani, Waleed

AU - Møller, Morten Hylander

AU - Arabi, Yaseen M.

AU - Loeb, Mark

AU - Gong, Michelle Ng

AU - Fan, Eddy

AU - Oczkowski, Simon

AU - Levy, Mitchell M.

AU - Derde, Lennie

AU - Dzierba, Amy

AU - Du, Bin

AU - Aboodi, Michael

AU - Wunsch, Hannah

AU - Cecconi, Maurizio

AU - Koh, Younsuck

AU - Chertow, Daniel S.

AU - Maitland, Kathryn

AU - Alshamsi, Fayez

AU - Belley-Cote, Emilie

AU - Greco, Massimiliano

AU - Laundy, Matthew

AU - Morgan, Jill S.

AU - Kesecioglu, Jozef

AU - McGeer, Allison

AU - Mermel, Leonard

AU - Mammen, Manoj J.

AU - Alexander, Paul E.

AU - Arrington, Amy

AU - Centofanti, John E.

AU - Citerio, Giuseppe

AU - Baw, Bandar

AU - Memish, Ziad A.

AU - Hammond, Naomi

AU - Hayden, Frederick G.

AU - Evans, Laura

AU - Rhodes, Andrew

PY - 2020

Y1 - 2020

N2 - Background: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent guidance for clinicians caring for the sickest of these patients is needed. Methods: We formed a panel of 36 experts from 12 countries. All panel members completed the World Health Organization conflict of interest disclosure form. The panel proposed 53 questions that are relevant to the management of COVID-19 in the ICU. We searched the literature for direct and indirect evidence on the management of COVID-19 in critically ill patients in the ICU. We identified relevant and recent systematic reviews on most questions relating to supportive care. We assessed the certainty in the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, then generated recommendations based on the balance between benefit and harm, resource and cost implications, equity, and feasibility. Recommendations were either strong or weak, or in the form of best practice recommendations. Results: The Surviving Sepsis Campaign COVID-19 panel issued 54 statements, of which 4 are best practice statements, 9 are strong recommendations, and 35 are weak recommendations. No recommendation was provided for 6 questions. The topics were: (1) infection control, (2) laboratory diagnosis and specimens, (3) hemodynamic support, (4) ventilatory support, and (5) COVID-19 therapy. Conclusion: The Surviving Sepsis Campaign COVID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19. When available, we will provide new recommendations in further releases of these guidelines.

AB - Background: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent guidance for clinicians caring for the sickest of these patients is needed. Methods: We formed a panel of 36 experts from 12 countries. All panel members completed the World Health Organization conflict of interest disclosure form. The panel proposed 53 questions that are relevant to the management of COVID-19 in the ICU. We searched the literature for direct and indirect evidence on the management of COVID-19 in critically ill patients in the ICU. We identified relevant and recent systematic reviews on most questions relating to supportive care. We assessed the certainty in the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, then generated recommendations based on the balance between benefit and harm, resource and cost implications, equity, and feasibility. Recommendations were either strong or weak, or in the form of best practice recommendations. Results: The Surviving Sepsis Campaign COVID-19 panel issued 54 statements, of which 4 are best practice statements, 9 are strong recommendations, and 35 are weak recommendations. No recommendation was provided for 6 questions. The topics were: (1) infection control, (2) laboratory diagnosis and specimens, (3) hemodynamic support, (4) ventilatory support, and (5) COVID-19 therapy. Conclusion: The Surviving Sepsis Campaign COVID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19. When available, we will provide new recommendations in further releases of these guidelines.

KW - Clinical practice guidelines

KW - Coronavirus

KW - COVID-19

KW - Critical illness

KW - SARS CoV-2

U2 - 10.1007/s00134-020-06022-5

DO - 10.1007/s00134-020-06022-5

M3 - Journal article

C2 - 32222812

AN - SCOPUS:85082772228

VL - 46

SP - 854

EP - 887

JO - European Journal of Intensive Care Medicine

JF - European Journal of Intensive Care Medicine

SN - 0935-1701

IS - 5

ER -