Survival of selected patients with ovarian cancer treated with fertility-sparing surgery
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Survival of selected patients with ovarian cancer treated with fertility-sparing surgery. / Hedbäck, Nora Elisabeth; Karlsen, Mona Aarenstrup; Høgdall, Claus Kim; Rosendahl, Mikkel.
In: Reproductive BioMedicine Online, Vol. 37, No. 1, 2018, p. 71-76.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Survival of selected patients with ovarian cancer treated with fertility-sparing surgery
AU - Hedbäck, Nora Elisabeth
AU - Karlsen, Mona Aarenstrup
AU - Høgdall, Claus Kim
AU - Rosendahl, Mikkel
N1 - Copyright © 2018. Published by Elsevier Ltd.
PY - 2018
Y1 - 2018
N2 - RESEARCH QUESTION: How many patients in Denmark were treated with fertility-sparing surgery (FSS) for epithelial ovarian cancer (EOC) and what was their prognosis compared with patients treated with radical surgery (RS)?DESIGN: This study was a retrospective Danish nationwide study, evaluating the effect of FSS compared with RS in patients with EOC, age ≤45 years and International Federation of Gynecology and Obstetrics (FIGO) stage ≤IC3 from 2005 to 2016.RESULTS: A total of 106 patients were included. Of these, 13 were treated with FSS and 93 were treated with RS. Median age was 27 versus 42 years (P < 0.0001). Overall survival did not differ significantly between the two groups. Overall survival rate in the FSS group was 100%, while the overall survival in the RS group was 87%. Disease-specific survival was 100% in the FSS group and 91% in the RS group.CONCLUSIONS: This study shows that patients treated with FSS for FIGO stage I EOC do not have an impaired survival compared with patients treated with RS. Nevertheless, the conclusion must be interpreted with caution due to the limited number of patients and the retrospective nature of the study. Larger studies are needed before conclusions can be drawn.
AB - RESEARCH QUESTION: How many patients in Denmark were treated with fertility-sparing surgery (FSS) for epithelial ovarian cancer (EOC) and what was their prognosis compared with patients treated with radical surgery (RS)?DESIGN: This study was a retrospective Danish nationwide study, evaluating the effect of FSS compared with RS in patients with EOC, age ≤45 years and International Federation of Gynecology and Obstetrics (FIGO) stage ≤IC3 from 2005 to 2016.RESULTS: A total of 106 patients were included. Of these, 13 were treated with FSS and 93 were treated with RS. Median age was 27 versus 42 years (P < 0.0001). Overall survival did not differ significantly between the two groups. Overall survival rate in the FSS group was 100%, while the overall survival in the RS group was 87%. Disease-specific survival was 100% in the FSS group and 91% in the RS group.CONCLUSIONS: This study shows that patients treated with FSS for FIGO stage I EOC do not have an impaired survival compared with patients treated with RS. Nevertheless, the conclusion must be interpreted with caution due to the limited number of patients and the retrospective nature of the study. Larger studies are needed before conclusions can be drawn.
KW - Adolescent
KW - Adult
KW - Denmark
KW - Disease-Free Survival
KW - Female
KW - Fertility Preservation/methods
KW - Humans
KW - Middle Aged
KW - Neoplasms, Glandular and Epithelial/mortality
KW - Organ Sparing Treatments/methods
KW - Ovarian Neoplasms/mortality
KW - Prognosis
KW - Retrospective Studies
KW - Survival Rate
KW - Treatment Outcome
KW - Young Adult
U2 - 10.1016/j.rbmo.2018.03.018
DO - 10.1016/j.rbmo.2018.03.018
M3 - Journal article
C2 - 29685481
VL - 37
SP - 71
EP - 76
JO - Reproductive BioMedicine Online
JF - Reproductive BioMedicine Online
SN - 1472-6483
IS - 1
ER -
ID: 217249995