Survival in Women Diagnosed With Breast Cancer During Pregnancy
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Survival in Women Diagnosed With Breast Cancer During Pregnancy. / Viuff, Jakob H.; Greiber, Iben K.; Karlsen, Mona Aa.; Storgaard, Lone; Kroman, Niels; Jensen, Maj Britt; Eibye, Simone; Hjortshøj, Cristel S.; Ejlertsen, Bent; Winther, Jeanette F.; Kjær, Susanne K.; Mellemkjær, Lene.
In: Clinical Breast Cancer, Vol. 22, No. 4, 2022, p. e517-e525.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Survival in Women Diagnosed With Breast Cancer During Pregnancy
AU - Viuff, Jakob H.
AU - Greiber, Iben K.
AU - Karlsen, Mona Aa.
AU - Storgaard, Lone
AU - Kroman, Niels
AU - Jensen, Maj Britt
AU - Eibye, Simone
AU - Hjortshøj, Cristel S.
AU - Ejlertsen, Bent
AU - Winther, Jeanette F.
AU - Kjær, Susanne K.
AU - Mellemkjær, Lene
N1 - Publisher Copyright: © 2021 Elsevier Inc.
PY - 2022
Y1 - 2022
N2 - Introduction: Pregnancy rarely coincides with breast cancer, but when it does, uncertainties remain about how survival is affected. In a nation-wide study, we investigated survival in women diagnosed with breast cancer during pregnancy. Materials and Methods: Through health registries, we identified women with breast cancer at ages 15-44 years from 1973-2016 in Denmark and included 156 who were pregnant at diagnosis and 11,110 who were not. We compared overall mortality in pregnant and non–pregnant women using multivariate Cox regression stratified by time since cancer: <2 and ≥2 years. Results: During the first 2 years after diagnosis, the hazard ratio of overall death was 2.28 (95% CI: 1.48-3.52) for pregnant versus non–pregnant breast cancer patients after adjustment for age and calendar period and 1.62 (95% CI: 1.05-2.50) after further adjustment for extent of disease. Adjusting for additional tumor characteristics, the hazard ratio was still significantly increased. Beyond the first 2 years, there was no excess mortality. Conclusion: Our study identifies the early period after breast cancer as a period of particular interest in future studies on survival after breast cancer in pregnancy. We found no evidence that survival is affected by pregnancy when 2 or more years have passed since diagnosis.
AB - Introduction: Pregnancy rarely coincides with breast cancer, but when it does, uncertainties remain about how survival is affected. In a nation-wide study, we investigated survival in women diagnosed with breast cancer during pregnancy. Materials and Methods: Through health registries, we identified women with breast cancer at ages 15-44 years from 1973-2016 in Denmark and included 156 who were pregnant at diagnosis and 11,110 who were not. We compared overall mortality in pregnant and non–pregnant women using multivariate Cox regression stratified by time since cancer: <2 and ≥2 years. Results: During the first 2 years after diagnosis, the hazard ratio of overall death was 2.28 (95% CI: 1.48-3.52) for pregnant versus non–pregnant breast cancer patients after adjustment for age and calendar period and 1.62 (95% CI: 1.05-2.50) after further adjustment for extent of disease. Adjusting for additional tumor characteristics, the hazard ratio was still significantly increased. Beyond the first 2 years, there was no excess mortality. Conclusion: Our study identifies the early period after breast cancer as a period of particular interest in future studies on survival after breast cancer in pregnancy. We found no evidence that survival is affected by pregnancy when 2 or more years have passed since diagnosis.
KW - Early follow-up
KW - Health registers
KW - Population-based
KW - Tumor characteristics
U2 - 10.1016/j.clbc.2021.11.009
DO - 10.1016/j.clbc.2021.11.009
M3 - Journal article
C2 - 34963614
AN - SCOPUS:85121831922
VL - 22
SP - e517-e525
JO - Clinical Breast Cancer
JF - Clinical Breast Cancer
SN - 1526-8209
IS - 4
ER -
ID: 314149007