Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease
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Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease. / Dalgård, Christine; Nielsen, Flemming Steen; Morrow, Jason D; Enghusen-Poulsen, Henrik; Jonung, Torbjörn; Hørder, Mogens; de Maat, Moniek P M.
In: British Journal of Nutrition, Vol. 101, No. 2, 2009, p. 263-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease
AU - Dalgård, Christine
AU - Nielsen, Flemming Steen
AU - Morrow, Jason D
AU - Enghusen-Poulsen, Henrik
AU - Jonung, Torbjörn
AU - Hørder, Mogens
AU - de Maat, Moniek P M
N1 - Keywords: Antioxidants; Beverages; Biological Markers; C-Reactive Protein; Citrus sinensis; Dietary Supplements; Female; Fibrinogen; Humans; Interleukin-6; Male; Middle Aged; Multivariate Analysis; Oxidative Stress; Peripheral Vascular Diseases; Ribes; Statistics, Nonparametric; Vitamin E; von Willebrand Factor
PY - 2009
Y1 - 2009
N2 - Inflammation and endothelial activation are associated with an increased risk of CVD and epidemiological evidence suggests an association between levels of markers of inflammation or endothelial activation and the intake of fruit. Also, vitamin E, a fat-soluble antioxidant, has anti-inflammatory properties. We performed a randomised 2 x 2 factorial, crossover trial to determine the effect of orange and blackcurrant juice (500 ml/d) and vitamin E (15 mg RRR-alpha-tocopherol/d) supplementation on markers of inflammation and endothelial activation in forty-eight patients with peripheral arterial disease. Patients were randomly allocated to two dietary supplements from the four possible combinations of juice and vitamin E: juice+vitamin E; juice+placebo; reference beverage (sugar drink)+vitamin E; and reference beverage+placebo. The supplementations were given for 28 d, separated by a 4-week wash-out period. Analysis of main effects showed that juice decreased C-reactive protein (CRP) by 11% and fibrinogen by 3% while the reference drink increased CRP by 13% and fibrinogen by 2% (P
AB - Inflammation and endothelial activation are associated with an increased risk of CVD and epidemiological evidence suggests an association between levels of markers of inflammation or endothelial activation and the intake of fruit. Also, vitamin E, a fat-soluble antioxidant, has anti-inflammatory properties. We performed a randomised 2 x 2 factorial, crossover trial to determine the effect of orange and blackcurrant juice (500 ml/d) and vitamin E (15 mg RRR-alpha-tocopherol/d) supplementation on markers of inflammation and endothelial activation in forty-eight patients with peripheral arterial disease. Patients were randomly allocated to two dietary supplements from the four possible combinations of juice and vitamin E: juice+vitamin E; juice+placebo; reference beverage (sugar drink)+vitamin E; and reference beverage+placebo. The supplementations were given for 28 d, separated by a 4-week wash-out period. Analysis of main effects showed that juice decreased C-reactive protein (CRP) by 11% and fibrinogen by 3% while the reference drink increased CRP by 13% and fibrinogen by 2% (P
U2 - 10.1017/S0007114508995660
DO - 10.1017/S0007114508995660
M3 - Journal article
C2 - 18507878
VL - 101
SP - 263
EP - 269
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 2
ER -
ID: 20736914