Suicidal Ideation and Non-Suicidal Self-Injury Following Early Childhood Psychotic Experiences in Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder-The Danish High Risk and Resilience Study, VIA 11
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Suicidal Ideation and Non-Suicidal Self-Injury Following Early Childhood Psychotic Experiences in Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder-The Danish High Risk and Resilience Study, VIA 11. / Gregersen, Maja; Jepsen, Jens Richardt Møllegaard; Brandt, Julie Marie; Sondergaard, Anne; Rohd, Sinnika Birkehoj; Veddum, Lotte; Knudsen, Christina Bruun; Andreassen, Anna Krogh; Burton, Birgitte Klee; Hjorthoj, Carsten; Krantz, Mette Falkenberg; Greve, Aja Neergaard; Bliksted, Vibeke; Mors, Ole; Nordentoft, Merete; Thorup, Anne Amalie Elgaard; Hemager, Nicoline.
In: Schizophrenia Bulletin, Vol. 49, No. 6, 2023, p. 1602–1613.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Suicidal Ideation and Non-Suicidal Self-Injury Following Early Childhood Psychotic Experiences in Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder-The Danish High Risk and Resilience Study, VIA 11
AU - Gregersen, Maja
AU - Jepsen, Jens Richardt Møllegaard
AU - Brandt, Julie Marie
AU - Sondergaard, Anne
AU - Rohd, Sinnika Birkehoj
AU - Veddum, Lotte
AU - Knudsen, Christina Bruun
AU - Andreassen, Anna Krogh
AU - Burton, Birgitte Klee
AU - Hjorthoj, Carsten
AU - Krantz, Mette Falkenberg
AU - Greve, Aja Neergaard
AU - Bliksted, Vibeke
AU - Mors, Ole
AU - Nordentoft, Merete
AU - Thorup, Anne Amalie Elgaard
AU - Hemager, Nicoline
PY - 2023
Y1 - 2023
N2 - Background and Hypothesis Suicide is a leading cause of death in youth and is often preceded by suicidal ideation (SI) and non-suicidal self-injury (NSSI). Identifying early markers of risk for SI and NSSI could improve timely identification of at-risk individuals. Study Design Children (mean age 11.9, SD 0.2) at familial high risk of schizophrenia (N = 171), or bipolar disorder (N = 104), and controls (N = 174) were assessed for psychotic experiences (PE), SI, NSSI, and Axis I mental disorders in face-to-face interviews in early and middle childhood (age 7 and 11). Study Results Having 2 types of early childhood PE predicted middle childhood SI after accounting for previous SI, NSSI, and mental disorders (OR 2.8, 95% CI 1.1-6.9; P = .03). Two PE predicted NSSI (OR 3.0, 95% CI 1.2-7.7; P = .02) in excess of previous SI, NSSI, mental disorders, and familial risk. Persistent and incident PE predicted SI (OR 3.2, 95% CI, 1.1-8.8; P = .03; OR 3.8, 95% CI, 1.3-11.5; P = .02) in the fully adjusted model. Nineteen percent of children with persistent PE reported middle childhood SI vs 3.8% of those who never reported PE. In children with early childhood mental disorders, those who reported 2 PE had 4.4-fold increased odds of later SI (95% CI, 1.2-16.7; P = .03) after adjustments. PE were nondifferentially associated with outcomes across familial risk groups. Conclusions Early childhood PE index elevated risk for subsequent SI and NSSI beyond what can be attributed to presence of mental disorders. Mental health screenings and clinical assessments should include early childhood PE.
AB - Background and Hypothesis Suicide is a leading cause of death in youth and is often preceded by suicidal ideation (SI) and non-suicidal self-injury (NSSI). Identifying early markers of risk for SI and NSSI could improve timely identification of at-risk individuals. Study Design Children (mean age 11.9, SD 0.2) at familial high risk of schizophrenia (N = 171), or bipolar disorder (N = 104), and controls (N = 174) were assessed for psychotic experiences (PE), SI, NSSI, and Axis I mental disorders in face-to-face interviews in early and middle childhood (age 7 and 11). Study Results Having 2 types of early childhood PE predicted middle childhood SI after accounting for previous SI, NSSI, and mental disorders (OR 2.8, 95% CI 1.1-6.9; P = .03). Two PE predicted NSSI (OR 3.0, 95% CI 1.2-7.7; P = .02) in excess of previous SI, NSSI, mental disorders, and familial risk. Persistent and incident PE predicted SI (OR 3.2, 95% CI, 1.1-8.8; P = .03; OR 3.8, 95% CI, 1.3-11.5; P = .02) in the fully adjusted model. Nineteen percent of children with persistent PE reported middle childhood SI vs 3.8% of those who never reported PE. In children with early childhood mental disorders, those who reported 2 PE had 4.4-fold increased odds of later SI (95% CI, 1.2-16.7; P = .03) after adjustments. PE were nondifferentially associated with outcomes across familial risk groups. Conclusions Early childhood PE index elevated risk for subsequent SI and NSSI beyond what can be attributed to presence of mental disorders. Mental health screenings and clinical assessments should include early childhood PE.
KW - Childhood
KW - adolescence
KW - subclinical psychosis
KW - suicide risk behaviors
KW - CROSS-NATIONAL ANALYSIS
KW - 7-YEAR-OLD CHILDREN
KW - PSYCHIATRIC-DISORDERS
KW - PROTECTIVE FACTORS
KW - META-REGRESSION
KW - METAANALYSIS
KW - SYMPTOMS
KW - PREVALENCE
KW - BEHAVIORS
KW - THOUGHTS
U2 - 10.1093/schbul/sbad052
DO - 10.1093/schbul/sbad052
M3 - Journal article
C2 - 37171862
VL - 49
SP - 1602
EP - 1613
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
SN - 0586-7614
IS - 6
ER -
ID: 347001666