Study protocol for examining job strain as a risk factor for severe unipolar depression in an individual participant meta-analysis of 14 European cohorts
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Study protocol for examining job strain as a risk factor for severe unipolar depression in an individual participant meta-analysis of 14 European cohorts. / Madsen, Ida E.H.; Hannerz, Harald; Nyberg, Solja T.; Magnusson Hanson, Linda L.; Ahola, Kirsi; Alfredsson, Lars; Batty, G. David; Bjorner, Jakob B.; Borritz, Marianne; Burr, Hermann; Dragano, Nico; Ferrie, Jane E.; Hamer, Mark; Jokela, Markus; Knutsson, Anders; Koskenvuo, Markku; Koskinen, Aki; Leineweber, Constanze; Nielsen, Martin L.; Nordin, Maria; Oksanen, Tuula; Pejtersen, Jan H.; Pentti, Jaana; Salo, Paula; Singh-Manoux, Archana; Suominen, Sakari; Theorell, Töres; Toppinen-Tanner, Salla; Vahtera, Jussi; Väänänen, Ari; Westerholm, Peter J.M.; Westerlund, Hugo; Fransson, Eleonor; Heikkilä, Katriina; Virtanen, Marianna; Rugulies, Reiner; Kivimäki, Mika.
In: F1000Research, Vol. 2, 2-233.v2, 2014.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Study protocol for examining job strain as a risk factor for severe unipolar depression in an individual participant meta-analysis of 14 European cohorts
AU - Madsen, Ida E.H.
AU - Hannerz, Harald
AU - Nyberg, Solja T.
AU - Magnusson Hanson, Linda L.
AU - Ahola, Kirsi
AU - Alfredsson, Lars
AU - Batty, G. David
AU - Bjorner, Jakob B.
AU - Borritz, Marianne
AU - Burr, Hermann
AU - Dragano, Nico
AU - Ferrie, Jane E.
AU - Hamer, Mark
AU - Jokela, Markus
AU - Knutsson, Anders
AU - Koskenvuo, Markku
AU - Koskinen, Aki
AU - Leineweber, Constanze
AU - Nielsen, Martin L.
AU - Nordin, Maria
AU - Oksanen, Tuula
AU - Pejtersen, Jan H.
AU - Pentti, Jaana
AU - Salo, Paula
AU - Singh-Manoux, Archana
AU - Suominen, Sakari
AU - Theorell, Töres
AU - Toppinen-Tanner, Salla
AU - Vahtera, Jussi
AU - Väänänen, Ari
AU - Westerholm, Peter J.M.
AU - Westerlund, Hugo
AU - Fransson, Eleonor
AU - Heikkilä, Katriina
AU - Virtanen, Marianna
AU - Rugulies, Reiner
AU - Kivimäki, Mika
N1 - Publisher Copyright: © 2014 Madsen IEH et al.
PY - 2014
Y1 - 2014
N2 - Background: Previous studies have shown that gainfully employed individuals with high work demands and low control at work (denoted "job strain?) are at increased risk of common mental disorders, including depression. Most existing studies have, however, measured depression using self-rated symptom scales that do not necessarily correspond to clinically diagnosed depression. In addition, a meta-analysis from 2008 indicated publication bias in the field. Methods: This study protocol describes the planned design and analyses of an individual participant data meta-analysis, to examine whether job strain is associated with an increased risk of clinically diagnosed unipolar depression based on hospital treatment registers. The study will be based on data from approximately 120,000 individuals who participated in 14 studies on work environment and health in 4 European countries. The self-reported working conditions data will be merged with national registers on psychiatric hospital treatment, primarily hospital admissions. Study-specific risk estimates for the association between job strain and depression will be calculated using Cox regressions. The study-specific risk estimates will be pooled using random effects meta-analysis. Discussion: The planned analyses will help clarify whether job strain is associated with an increased risk of clinically diagnosed unipolar depression. As the analysis is based on pre-planned study protocols and an individual participant data meta-analysis, the pooled risk estimates will not be influenced by selective reporting and publication bias. However, the results of the planned study may only pertain to severe cases of unipolar depression, because of the outcome measure applied.
AB - Background: Previous studies have shown that gainfully employed individuals with high work demands and low control at work (denoted "job strain?) are at increased risk of common mental disorders, including depression. Most existing studies have, however, measured depression using self-rated symptom scales that do not necessarily correspond to clinically diagnosed depression. In addition, a meta-analysis from 2008 indicated publication bias in the field. Methods: This study protocol describes the planned design and analyses of an individual participant data meta-analysis, to examine whether job strain is associated with an increased risk of clinically diagnosed unipolar depression based on hospital treatment registers. The study will be based on data from approximately 120,000 individuals who participated in 14 studies on work environment and health in 4 European countries. The self-reported working conditions data will be merged with national registers on psychiatric hospital treatment, primarily hospital admissions. Study-specific risk estimates for the association between job strain and depression will be calculated using Cox regressions. The study-specific risk estimates will be pooled using random effects meta-analysis. Discussion: The planned analyses will help clarify whether job strain is associated with an increased risk of clinically diagnosed unipolar depression. As the analysis is based on pre-planned study protocols and an individual participant data meta-analysis, the pooled risk estimates will not be influenced by selective reporting and publication bias. However, the results of the planned study may only pertain to severe cases of unipolar depression, because of the outcome measure applied.
U2 - 10.12688/f1000research.2-233.v2
DO - 10.12688/f1000research.2-233.v2
M3 - Journal article
AN - SCOPUS:84914811130
VL - 2
JO - F1000Research
JF - F1000Research
SN - 2046-1402
M1 - 2-233.v2
ER -
ID: 387296426