Somatosensory function is impaired in patients with idiopathic REM sleep behaviour disorder

Research output: Contribution to journal › Journal article › Research › peer-review

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Somatosensory function is impaired in patients with idiopathic REM sleep behaviour disorder. / Strobel, A V; Tankisi, H; Finnerup, N B; Fuglsang-Frederiksen, A; Jennum, P; Svendsen, K B; Kirov, F I; Otto, M.

In: Sleep Medicine, Vol. 42, 2018, p. 83-89.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Strobel, AV, Tankisi, H, Finnerup, NB, Fuglsang-Frederiksen, A, Jennum, P, Svendsen, KB, Kirov, FI & Otto, M 2018, 'Somatosensory function is impaired in patients with idiopathic REM sleep behaviour disorder', Sleep Medicine, vol. 42, pp. 83-89. https://doi.org/10.1016/j.sleep.2017.09.035

APA

Strobel, A. V., Tankisi, H., Finnerup, N. B., Fuglsang-Frederiksen, A., Jennum, P., Svendsen, K. B., Kirov, F. I., & Otto, M. (2018). Somatosensory function is impaired in patients with idiopathic REM sleep behaviour disorder. Sleep Medicine, 42, 83-89. https://doi.org/10.1016/j.sleep.2017.09.035

Vancouver

Strobel AV, Tankisi H, Finnerup NB, Fuglsang-Frederiksen A, Jennum P, Svendsen KB et al. Somatosensory function is impaired in patients with idiopathic REM sleep behaviour disorder. Sleep Medicine. 2018;42:83-89. https://doi.org/10.1016/j.sleep.2017.09.035

Author

Strobel, A V ; Tankisi, H ; Finnerup, N B ; Fuglsang-Frederiksen, A ; Jennum, P ; Svendsen, K B ; Kirov, F I ; Otto, M. / Somatosensory function is impaired in patients with idiopathic REM sleep behaviour disorder. In: Sleep Medicine. 2018 ; Vol. 42. pp. 83-89.

Bibtex

@article{bd1db7c64dd4441abc55c67f23bbac2d,
title = "Somatosensory function is impaired in patients with idiopathic REM sleep behaviour disorder",
abstract = "BACKGROUND: Idiopathic REM sleep behaviour disorder (iRBD) has been recognised as a significant biomarker for developing a neurodegenerative alpha-synucleinopathy, which is why iRBD is considered to be a prodromal state for alpha-synucleinopathies including Parkinson's disease (PD). Many patients with PD suffer from complaints of pain and present impaired somatosensory function. We hypothesized that pain perception and somatosensory function could be altered already in a preclinical stage of PD including iRBD. Hence, the objective of this study was to investigate pain perception and somatosensory function in patients with iRBD.METHODS: Quantitative sensory testing (QST), laser evoked potentials (LEPs), and conditioned pain modulation (CPM) testing were performed in 13 iRBD patients without any clinical signs of PD or narcolepsy (11 males, 2 females, mean age 65.2 years) and 15 gender- and age-matched healthy control subjects (12 males, 3 females, mean age 65.8 years).RESULTS: Thermal detection thresholds were higher in the iRBD group compared with the control group (cold detection threshold (CDT) p = 0.020, thermal sensory limen (TSL) p = 0.001), indicating an impaired temperature sensation in iRBD patients. The N2/P2 LEPs amplitude was smaller in iRBD patients than controls, but not statistically significant (p = 0.053).CONCLUSIONS: This study found an impaired somatosensory function in iRBD patients, suggesting that somatosensory impairment might be an early feature in the neurodegenerative process of PD.",
author = "Strobel, {A V} and H Tankisi and Finnerup, {N B} and A Fuglsang-Frederiksen and P Jennum and Svendsen, {K B} and Kirov, {F I} and M Otto",
note = "Copyright {\textcopyright} 2017 The Authors. Published by Elsevier B.V. All rights reserved.",
year = "2018",
doi = "10.1016/j.sleep.2017.09.035",
language = "English",
volume = "42",
pages = "83--89",
journal = "Sleep Medicine",
issn = "1389-9457",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Somatosensory function is impaired in patients with idiopathic REM sleep behaviour disorder

AU - Strobel, A V

AU - Tankisi, H

AU - Finnerup, N B

AU - Fuglsang-Frederiksen, A

AU - Jennum, P

AU - Svendsen, K B

AU - Kirov, F I

AU - Otto, M

N1 - Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Idiopathic REM sleep behaviour disorder (iRBD) has been recognised as a significant biomarker for developing a neurodegenerative alpha-synucleinopathy, which is why iRBD is considered to be a prodromal state for alpha-synucleinopathies including Parkinson's disease (PD). Many patients with PD suffer from complaints of pain and present impaired somatosensory function. We hypothesized that pain perception and somatosensory function could be altered already in a preclinical stage of PD including iRBD. Hence, the objective of this study was to investigate pain perception and somatosensory function in patients with iRBD.METHODS: Quantitative sensory testing (QST), laser evoked potentials (LEPs), and conditioned pain modulation (CPM) testing were performed in 13 iRBD patients without any clinical signs of PD or narcolepsy (11 males, 2 females, mean age 65.2 years) and 15 gender- and age-matched healthy control subjects (12 males, 3 females, mean age 65.8 years).RESULTS: Thermal detection thresholds were higher in the iRBD group compared with the control group (cold detection threshold (CDT) p = 0.020, thermal sensory limen (TSL) p = 0.001), indicating an impaired temperature sensation in iRBD patients. The N2/P2 LEPs amplitude was smaller in iRBD patients than controls, but not statistically significant (p = 0.053).CONCLUSIONS: This study found an impaired somatosensory function in iRBD patients, suggesting that somatosensory impairment might be an early feature in the neurodegenerative process of PD.

AB - BACKGROUND: Idiopathic REM sleep behaviour disorder (iRBD) has been recognised as a significant biomarker for developing a neurodegenerative alpha-synucleinopathy, which is why iRBD is considered to be a prodromal state for alpha-synucleinopathies including Parkinson's disease (PD). Many patients with PD suffer from complaints of pain and present impaired somatosensory function. We hypothesized that pain perception and somatosensory function could be altered already in a preclinical stage of PD including iRBD. Hence, the objective of this study was to investigate pain perception and somatosensory function in patients with iRBD.METHODS: Quantitative sensory testing (QST), laser evoked potentials (LEPs), and conditioned pain modulation (CPM) testing were performed in 13 iRBD patients without any clinical signs of PD or narcolepsy (11 males, 2 females, mean age 65.2 years) and 15 gender- and age-matched healthy control subjects (12 males, 3 females, mean age 65.8 years).RESULTS: Thermal detection thresholds were higher in the iRBD group compared with the control group (cold detection threshold (CDT) p = 0.020, thermal sensory limen (TSL) p = 0.001), indicating an impaired temperature sensation in iRBD patients. The N2/P2 LEPs amplitude was smaller in iRBD patients than controls, but not statistically significant (p = 0.053).CONCLUSIONS: This study found an impaired somatosensory function in iRBD patients, suggesting that somatosensory impairment might be an early feature in the neurodegenerative process of PD.

U2 - 10.1016/j.sleep.2017.09.035

DO - 10.1016/j.sleep.2017.09.035

M3 - Journal article

C2 - 29458751

VL - 42

SP - 83

EP - 89

JO - Sleep Medicine

JF - Sleep Medicine

SN - 1389-9457

ER -

ID: 218089108