Soluble CD163 predicts incident chronic lung, kidney and liver disease in HIV infection
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Soluble CD163 predicts incident chronic lung, kidney and liver disease in HIV infection. / Kirkegaard-Klitbo, Ditte M; Mejer, Niels; Knudsen, Troels B; Møller, Holger J; Moestrup, Søren K; Poulsen, Susanne D; Kronborg, Gitte; Benfield, Thomas.
In: AIDS (London, England), Vol. 31, No. 7, 24.04.2017, p. 981-988.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Soluble CD163 predicts incident chronic lung, kidney and liver disease in HIV infection
AU - Kirkegaard-Klitbo, Ditte M
AU - Mejer, Niels
AU - Knudsen, Troels B
AU - Møller, Holger J
AU - Moestrup, Søren K
AU - Poulsen, Susanne D
AU - Kronborg, Gitte
AU - Benfield, Thomas
PY - 2017/4/24
Y1 - 2017/4/24
N2 - OBJECTIVE: To examine if monocyte and macrophage activity may be on the mechanistic pathway to non-AIDS comorbidity by investigating the associations between plasma-soluble CD163 (sCD163) and incident non-AIDS comorbidities in well treated HIV-infected individuals.DESIGN: Prospective single-center cohort study.METHODS: Plasma sCD163 was quantified by ELISA technique at study entry in 2004/2005, and non-AIDS comorbidity was identified by International Classification of Disease Tenth revision diagnosis codes and registry linkage in 2014/2015. Associations between sCD163 and incident comorbidity was examined using multivariable Cox proportional hazards models adjusted for pertinent covariates.RESULTS: In HIV-1-infected individuals (n = 799), the highest quartile of plasma sCD163 was associated with incident chronic lung disease [adjusted hazard ratio (aHR), 3.2; 95% confidence interval (CI): 1.34; 7.46] and incident chronic kidney disease (aHR, 10.94; 95% CI: 2.32; 51.35), when compared with lowest quartiles. Further, (every 1 mg) increase in plasma sCD163 was positively correlated with incident liver disease (aHR, 1.12; 95% CI: 1.05; 1.19). The sCD163 level was not associated with incident cancer, cardiovascular disease or diabetes mellitus.CONCLUSION: sCD163 was independently associated with incident chronic kidney disease, chronic lung disease and liver disease in treated HIV-1-infected individuals, suggesting that monocyte/macrophage activation may be involved in the pathogenesis of non-AIDS comorbidity and a potential target for therapeutic intervention.
AB - OBJECTIVE: To examine if monocyte and macrophage activity may be on the mechanistic pathway to non-AIDS comorbidity by investigating the associations between plasma-soluble CD163 (sCD163) and incident non-AIDS comorbidities in well treated HIV-infected individuals.DESIGN: Prospective single-center cohort study.METHODS: Plasma sCD163 was quantified by ELISA technique at study entry in 2004/2005, and non-AIDS comorbidity was identified by International Classification of Disease Tenth revision diagnosis codes and registry linkage in 2014/2015. Associations between sCD163 and incident comorbidity was examined using multivariable Cox proportional hazards models adjusted for pertinent covariates.RESULTS: In HIV-1-infected individuals (n = 799), the highest quartile of plasma sCD163 was associated with incident chronic lung disease [adjusted hazard ratio (aHR), 3.2; 95% confidence interval (CI): 1.34; 7.46] and incident chronic kidney disease (aHR, 10.94; 95% CI: 2.32; 51.35), when compared with lowest quartiles. Further, (every 1 mg) increase in plasma sCD163 was positively correlated with incident liver disease (aHR, 1.12; 95% CI: 1.05; 1.19). The sCD163 level was not associated with incident cancer, cardiovascular disease or diabetes mellitus.CONCLUSION: sCD163 was independently associated with incident chronic kidney disease, chronic lung disease and liver disease in treated HIV-1-infected individuals, suggesting that monocyte/macrophage activation may be involved in the pathogenesis of non-AIDS comorbidity and a potential target for therapeutic intervention.
KW - Journal Article
U2 - 10.1097/QAD.0000000000001432
DO - 10.1097/QAD.0000000000001432
M3 - Journal article
C2 - 28252527
VL - 31
SP - 981
EP - 988
JO - AIDS
JF - AIDS
SN - 1350-2840
IS - 7
ER -
ID: 186158546