Size and number of food boluses in the stomach after eating different meals: Magnetic resonance imaging insights in healthy humans
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Size and number of food boluses in the stomach after eating different meals : Magnetic resonance imaging insights in healthy humans. / Hornby, Hannah; Collado-González, Mar; Zhang, Xue; Abrehart, Nichola; Alshammari, Meshari; Bakalis, Serafim; Mackie, Alan; Marciani, Luca.
In: Nutrients, Vol. 13, No. 10, 3626, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Size and number of food boluses in the stomach after eating different meals
T2 - Magnetic resonance imaging insights in healthy humans
AU - Hornby, Hannah
AU - Collado-González, Mar
AU - Zhang, Xue
AU - Abrehart, Nichola
AU - Alshammari, Meshari
AU - Bakalis, Serafim
AU - Mackie, Alan
AU - Marciani, Luca
N1 - This article belongs to the Section Nutrition and Metabolism.
PY - 2021
Y1 - 2021
N2 - Oral processing of food results in the formation of food boluses, which are then swallowed and reach the stomach for further digestion. The number, size and surface properties of the boluses will affect their processing and emptying from the stomach. Knowledge of these parameters, however, is incomplete due to limitations of the techniques used. In this work, non-invasive magnetic resonance imaging (MRI) was used for the first time to measure boluses in the stomach a few minutes after swallowing. Three groups of nine healthy participants were fed three different meals: chicken and roasted vegetables (Meal 1), bread and jam (Meal 2) and cheese and yogurt (Meal 3), and then, their stomach content was imaged. The median number of boluses within the stomach was 282, 106 and 9 for Meal 1, Meal 2 and Meal 3 (p < 0.0001) with an average volume of 0.47 mL, 2.4 mL and 13.6 mL, respectively (p < 0.0001). The cohesiveness as well as the meal composition seem to play a key role in the resulting boluses. These new in vivo data from undisturbed organ imaging can improve knowledge of the digestion process, which will, in turn, inform in vitro and in silico modelling of digestion, thus improving their in vitro/in vivo relevance.
AB - Oral processing of food results in the formation of food boluses, which are then swallowed and reach the stomach for further digestion. The number, size and surface properties of the boluses will affect their processing and emptying from the stomach. Knowledge of these parameters, however, is incomplete due to limitations of the techniques used. In this work, non-invasive magnetic resonance imaging (MRI) was used for the first time to measure boluses in the stomach a few minutes after swallowing. Three groups of nine healthy participants were fed three different meals: chicken and roasted vegetables (Meal 1), bread and jam (Meal 2) and cheese and yogurt (Meal 3), and then, their stomach content was imaged. The median number of boluses within the stomach was 282, 106 and 9 for Meal 1, Meal 2 and Meal 3 (p < 0.0001) with an average volume of 0.47 mL, 2.4 mL and 13.6 mL, respectively (p < 0.0001). The cohesiveness as well as the meal composition seem to play a key role in the resulting boluses. These new in vivo data from undisturbed organ imaging can improve knowledge of the digestion process, which will, in turn, inform in vitro and in silico modelling of digestion, thus improving their in vitro/in vivo relevance.
KW - Bolus size
KW - Digestion
KW - Distribution
KW - In vivo
KW - Intragastric
KW - Meal composition
KW - MRI
U2 - 10.3390/nu13103626
DO - 10.3390/nu13103626
M3 - Journal article
C2 - 34684627
AN - SCOPUS:85117035644
VL - 13
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 10
M1 - 3626
ER -
ID: 283018464