Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex
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Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex. / Chen, Ao; Sun, Yidi; Lei, Ying; Li, Chao; Liao, Sha; Meng, Juan; Bai, Yiqin; Liu, Zhen; Liang, Zhifeng; Zhu, Zhiyong; Yuan, Nini; Yang, Hao; Wu, Zihan; Lin, Feng; Wang, Kexin; Li, Mei; Zhang, Shuzhen; Yang, Meisong; Fei, Tianyi; Zhuang, Zhenkun; Huang, Yiming; Zhang, Yong; Xu, Yuanfang; Cui, Luman; Zhang, Ruiyi; Han, Lei; Sun, Xing; Chen, Bichao; Li, Wenjiao; Huangfu, Baoqian; Ma, Kailong; Ma, Jianyun; Li, Zhao; Lin, Yikun; Wang, He; Zhong, Yanqing; Zhang, Huifang; Yu, Qian; Wang, Yaqian; Liu, Xing; Peng, Jian; Liu, Chuanyu; Chen, Wei; Pan, Wentao; An, Yingjie; Xia, Shihui; Lu, Yanbing; Wang, Mingli; Song, Xinxiang; Liu, Shuai; Wang, Zhifeng; Gong, Chun; Huang, Xin; Yuan, Yue; Zhao, Yun; Chai, Qinwen; Tan, Xing; Liu, Jianfeng; Zheng, Mingyuan; Li, Shengkang; Huang, Yaling; Hong, Yan; Huang, Zirui; Li, Min; Jin, Mengmeng; Li, Yan; Zhang, Hui; Sun, Suhong; Gao, Li; Bai, Yinqi; Cheng, Mengnan; Hu, Guohai; Liu, Shiping; Wang, Bo; Xiang, Bin; Li, Shuting; Li, Huanhuan; Chen, Mengni; Wang, Shiwen; Li, Minglong; Liu, Weibin; Liu, Xin; Zhao, Qian; Lisby, Michael; Wang, Jing; Fang, Jiao; Lin, Yun; Xie, Qing; He, Jie; Xu, Huatai; Huang, Wei; Mulder, Jan; Yang, Huanming; Sun, Yangang; Uhlen, Mathias; Poo, Muming; Wang, Jian; Yao, Jianhua; Wei, Wu; Li, Yuxiang; Shen, Zhiming; Liu, Longqi; Liu, Zhiyong; Xu, Xun; Li, Chengyu.
In: Cell, Vol. 186, No. 17, 2023, p. 3726-3743.e24.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex
AU - Chen, Ao
AU - Sun, Yidi
AU - Lei, Ying
AU - Li, Chao
AU - Liao, Sha
AU - Meng, Juan
AU - Bai, Yiqin
AU - Liu, Zhen
AU - Liang, Zhifeng
AU - Zhu, Zhiyong
AU - Yuan, Nini
AU - Yang, Hao
AU - Wu, Zihan
AU - Lin, Feng
AU - Wang, Kexin
AU - Li, Mei
AU - Zhang, Shuzhen
AU - Yang, Meisong
AU - Fei, Tianyi
AU - Zhuang, Zhenkun
AU - Huang, Yiming
AU - Zhang, Yong
AU - Xu, Yuanfang
AU - Cui, Luman
AU - Zhang, Ruiyi
AU - Han, Lei
AU - Sun, Xing
AU - Chen, Bichao
AU - Li, Wenjiao
AU - Huangfu, Baoqian
AU - Ma, Kailong
AU - Ma, Jianyun
AU - Li, Zhao
AU - Lin, Yikun
AU - Wang, He
AU - Zhong, Yanqing
AU - Zhang, Huifang
AU - Yu, Qian
AU - Wang, Yaqian
AU - Liu, Xing
AU - Peng, Jian
AU - Liu, Chuanyu
AU - Chen, Wei
AU - Pan, Wentao
AU - An, Yingjie
AU - Xia, Shihui
AU - Lu, Yanbing
AU - Wang, Mingli
AU - Song, Xinxiang
AU - Liu, Shuai
AU - Wang, Zhifeng
AU - Gong, Chun
AU - Huang, Xin
AU - Yuan, Yue
AU - Zhao, Yun
AU - Chai, Qinwen
AU - Tan, Xing
AU - Liu, Jianfeng
AU - Zheng, Mingyuan
AU - Li, Shengkang
AU - Huang, Yaling
AU - Hong, Yan
AU - Huang, Zirui
AU - Li, Min
AU - Jin, Mengmeng
AU - Li, Yan
AU - Zhang, Hui
AU - Sun, Suhong
AU - Gao, Li
AU - Bai, Yinqi
AU - Cheng, Mengnan
AU - Hu, Guohai
AU - Liu, Shiping
AU - Wang, Bo
AU - Xiang, Bin
AU - Li, Shuting
AU - Li, Huanhuan
AU - Chen, Mengni
AU - Wang, Shiwen
AU - Li, Minglong
AU - Liu, Weibin
AU - Liu, Xin
AU - Zhao, Qian
AU - Lisby, Michael
AU - Wang, Jing
AU - Fang, Jiao
AU - Lin, Yun
AU - Xie, Qing
AU - He, Jie
AU - Xu, Huatai
AU - Huang, Wei
AU - Mulder, Jan
AU - Yang, Huanming
AU - Sun, Yangang
AU - Uhlen, Mathias
AU - Poo, Muming
AU - Wang, Jian
AU - Yao, Jianhua
AU - Wei, Wu
AU - Li, Yuxiang
AU - Shen, Zhiming
AU - Liu, Longqi
AU - Liu, Zhiyong
AU - Xu, Xun
AU - Li, Chengyu
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2023
Y1 - 2023
N2 - Elucidating the cellular organization of the cerebral cortex is critical for understanding brain structure and function. Using large-scale single-nucleus RNA sequencing and spatial transcriptomic analysis of 143 macaque cortical regions, we obtained a comprehensive atlas of 264 transcriptome-defined cortical cell types and mapped their spatial distribution across the entire cortex. We characterized the cortical layer and region preferences of glutamatergic, GABAergic, and non-neuronal cell types, as well as regional differences in cell-type composition and neighborhood complexity. Notably, we discovered a relationship between the regional distribution of various cell types and the region's hierarchical level in the visual and somatosensory systems. Cross-species comparison of transcriptomic data from human, macaque, and mouse cortices further revealed primate-specific cell types that are enriched in layer 4, with their marker genes expressed in a region-dependent manner. Our data provide a cellular and molecular basis for understanding the evolution, development, aging, and pathogenesis of the primate brain.
AB - Elucidating the cellular organization of the cerebral cortex is critical for understanding brain structure and function. Using large-scale single-nucleus RNA sequencing and spatial transcriptomic analysis of 143 macaque cortical regions, we obtained a comprehensive atlas of 264 transcriptome-defined cortical cell types and mapped their spatial distribution across the entire cortex. We characterized the cortical layer and region preferences of glutamatergic, GABAergic, and non-neuronal cell types, as well as regional differences in cell-type composition and neighborhood complexity. Notably, we discovered a relationship between the regional distribution of various cell types and the region's hierarchical level in the visual and somatosensory systems. Cross-species comparison of transcriptomic data from human, macaque, and mouse cortices further revealed primate-specific cell types that are enriched in layer 4, with their marker genes expressed in a region-dependent manner. Our data provide a cellular and molecular basis for understanding the evolution, development, aging, and pathogenesis of the primate brain.
KW - cell-type organization
KW - hierarchy
KW - macaque cortex
KW - single-cell
KW - spatial transcriptome
U2 - 10.1016/j.cell.2023.06.009
DO - 10.1016/j.cell.2023.06.009
M3 - Journal article
C2 - 37442136
AN - SCOPUS:85167841501
VL - 186
SP - 3726-3743.e24
JO - Cell
JF - Cell
SN - 0092-8674
IS - 17
ER -
ID: 363353182