Short-term study of the uptake of PrPSc by the Peyer’s patches in hamsters after oral exposure to scrapie
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Short-term study of the uptake of PrPSc by the Peyer’s patches in hamsters after oral exposure to scrapie. / Bergström, Ann-Louise; Jensen, Tim Kåre; Heegaard, Peter; Hvass, Henriette Cordes; Hansen, V. B.; Laursen, H.; Lind, Peter.
In: Journal of Comparative Pathology, Vol. 134, No. 2-3, 2006, p. 126-133.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Short-term study of the uptake of PrPSc by the Peyer’s patches in hamsters after oral exposure to scrapie
AU - Bergström, Ann-Louise
AU - Jensen, Tim Kåre
AU - Heegaard, Peter
AU - Hvass, Henriette Cordes
AU - Hansen, V. B.
AU - Laursen, H.
AU - Lind, Peter
PY - 2006
Y1 - 2006
N2 - The disease-associated prion protein (PrPSc) has been detected in the ileal Peyer's patches of lambs as early as one week after oral exposure to scrapie. In hamsters, the earliest reported time of PrPSc detection in the Peyer's patches after oral exposure to scrapie is 69 days post-infection. To evaluate the acute uptake of inoculum and to investigate whether the Peyer's patches constitute the primary site of entry for scrapie after oral exposure, hamsters were each exposed orally to 1 ml of a 10% brain homogenate from hamsters in the terminal stage of infection with the 263 K strain of the scrapie agent. PrPSc was demonstrated in the Peyer's patches only a few days after exposure, i.e., much earlier than previously reported. This study Supports the view that the Peyer's patches constitute at least one of the primary entry sites of PrPSc after oral exposure to scrapie.
AB - The disease-associated prion protein (PrPSc) has been detected in the ileal Peyer's patches of lambs as early as one week after oral exposure to scrapie. In hamsters, the earliest reported time of PrPSc detection in the Peyer's patches after oral exposure to scrapie is 69 days post-infection. To evaluate the acute uptake of inoculum and to investigate whether the Peyer's patches constitute the primary site of entry for scrapie after oral exposure, hamsters were each exposed orally to 1 ml of a 10% brain homogenate from hamsters in the terminal stage of infection with the 263 K strain of the scrapie agent. PrPSc was demonstrated in the Peyer's patches only a few days after exposure, i.e., much earlier than previously reported. This study Supports the view that the Peyer's patches constitute at least one of the primary entry sites of PrPSc after oral exposure to scrapie.
U2 - 10.1016/j.jcpa.2005.08.002
DO - 10.1016/j.jcpa.2005.08.002
M3 - Journal article
VL - 134
SP - 126
EP - 133
JO - Journal of Comparative Pathology
JF - Journal of Comparative Pathology
SN - 0021-9975
IS - 2-3
ER -
ID: 339890695