Short- and Long-Term Outcomes After Multimodal Treatment of Pancreatic Duct Leakage in Patients With Chronic Pancreatitis
Research output: Contribution to journal › Journal article › Research › peer-review
OBJECTIVES: In patients with chronic pancreatitis, pancreatic duct leakage is associated with a prolonged disease course and serious complications. We aimed to assess the efficacy of this multimodal treatment of pancreatic duct leakage.
METHODS: In a retrospective design, patients with chronic pancreatitis, an amylase content greater than 200 U/L in either ascites or pleural fluid and treated between 2011 and 2020, were evaluated. The primary end point was treatment success.
RESULTS: Twenty-seven patients (22 males, median age 60, median American Society of Anesthesiologists score 3) were included.Endoscopic retrograde pancreatography was performed in 23 patients (85%) with transpapillary stenting of the main pancreatic duct in 22 patients (96%). Pancreatic sphincterotomy and dilation of the main pancreatic duct were done in 14 patients (61%) and 17 patients (74%), respectively. Twelve patients (44%) were treated with somatostatin analogs, parenteral nutrition, and were "nil by mouth" for a median of 11 days (range, 4-34 days). Six patients (22%) had extracorporeal shock wave lithotripsy due to pancreatic duct stones. One patient (4%) was referred for surgery. All 23 patients (100%) were treated with success after a median of 21 days (range, 5-80 days).
CONCLUSIONS: Multimodal treatment of pancreatic duct leakage is effective, with minimal need for surgery.
Original language | English |
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Journal | Pancreas |
Volume | 51 |
Issue number | 10 |
Pages (from-to) | 1315-1319 |
Number of pages | 5 |
ISSN | 0885-3177 |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
- Male, Humans, Middle Aged, Cholangiopancreatography, Endoscopic Retrograde, Retrospective Studies, Calculi/complications, Pancreatic Diseases/therapy, Pancreatitis, Chronic/complications, Pancreatic Ducts/surgery, Lithotripsy, Treatment Outcome, Combined Modality Therapy
Research areas
ID: 393849843