TY - JOUR

T1 - Sexual health and testosterone concentration in male lymphoma survivors

T2 - A systematic review

AU - Micas Pedersen, Signe

AU - Hersby, Ditte Stampe

AU - Jarden, Mary

AU - Nielsen, Torsten Holm

AU - Gang, Anne Ortved

AU - Poulsen, Christian Bjørn

AU - de Nully Brown, Peter

AU - Jørgensen, Niels

AU - Feltoft, Claus Larsen

AU - Pedersen, Lars Møller

N1 - Publisher Copyright: © 2024 The Authors

PY - 2024

Y1 - 2024

N2 - Advancements in lymphoma treatment have increased the number of long-term survivors who may experience late effects such as impaired sexual function and testosterone deficiency. The aim of this review was to determine the prevalence of testosterone deficiency and sexual dysfunction among male lymphoma survivors; and associations between the two. A systematic search identified 20 articles for inclusion. The prevalence of low total testosterone was 0%–50 %, with mean values within reference levels, and for luteinizing hormone above reference levels in 0%–80 %. Four studies included SHBG and free testosterone, with mixed results. Compromised sexual health was found in 23%–61 %. Overall, total testosterone and sexual health were associated. The risk of bias (ROBINS-E and RoB 2) was high/very high, leading to low/very low overall confidence in the bulk of evidence (GRADE). Longitudinal studies evaluating biologically active testosterone and sexual health are needed, to develop evidence based standard procedures for follow-up of sexual health.

AB - Advancements in lymphoma treatment have increased the number of long-term survivors who may experience late effects such as impaired sexual function and testosterone deficiency. The aim of this review was to determine the prevalence of testosterone deficiency and sexual dysfunction among male lymphoma survivors; and associations between the two. A systematic search identified 20 articles for inclusion. The prevalence of low total testosterone was 0%–50 %, with mean values within reference levels, and for luteinizing hormone above reference levels in 0%–80 %. Four studies included SHBG and free testosterone, with mixed results. Compromised sexual health was found in 23%–61 %. Overall, total testosterone and sexual health were associated. The risk of bias (ROBINS-E and RoB 2) was high/very high, leading to low/very low overall confidence in the bulk of evidence (GRADE). Longitudinal studies evaluating biologically active testosterone and sexual health are needed, to develop evidence based standard procedures for follow-up of sexual health.

KW - Androgen

KW - Erectile dysfunction

KW - Hypogonadism

KW - Lymphoma

KW - Sexual health

KW - Survivor

KW - Testosterone

KW - Testosterone deficiency

U2 - 10.1016/j.heliyon.2024.e31915

DO - 10.1016/j.heliyon.2024.e31915

M3 - Journal article

AN - SCOPUS:85195302056

VL - 10

JO - Heliyon

JF - Heliyon

SN - 2405-8440

IS - 11

M1 - e31915

ER -