Sex differences in the prognosis of nonsustained ventricular tachycardia detected on Holter recording
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Background: Nonsustained ventricular tachycardia (NSVT) is a common finding during cardiac evaluation and has been linked to increased mortality. While some studies report a sex difference, most data stem from research cohorts. Objective: This study aimed to assess the prognostic significance of NSVT in a real-life outpatient clinic, focusing on sex differences in mortality. Methods: Analysis was performed on a cohort of consecutive patients referred to 48-hour Holter monitoring between 2009 and 2011 at Copenhagen University Hospital – Bispebjerg. Indications for Holter monitoring included palpitations, dizziness, syncope, or arrhythmia testing. Baseline characteristics, blood tests, echocardiography results, and mortality data were obtained from electronic patient records. Results: A total of 762 females (mean age 59 ± 18 years) and 693 males (mean age 59 ± 17 years) were enrolled. At least 1 episode of NSVT was detected in 9.7% of females and 20.6% of males. The median follow-up was 8.3 years. A total of 20% of females and 24% of males died during follow-up. In multivariable models, NSVT was linked to mortality in males (hazard ratio [HR] 1.6, 95% confidence interval [CI] 1.1–2.3) but not in females (HR 1.2, 95% CI 0.7–2.1). In case-control pairs matched on the propensity of being male conditional on relevant risk factors, NSVT was again linked to mortality in males (HR 3.1, 95% CI 2.0–4.8) but not in females (HR 1.4, 95% CI 0.8–2.4). Conclusion: In consecutive patients referred to symptom driven Holter monitoring, NSVT was associated with elevated all-cause mortality in males but not in females. These results can contribute to the risk assessment of patients presenting with NSVT.
Original language | English |
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Journal | Heart Rhythm O2 |
Volume | 5 |
Issue number | 7 |
Pages (from-to) | 427-434 |
ISSN | 2666-5018 |
DOIs | |
Publication status | Published - 2024 |
Bibliographical note
Publisher Copyright:
© 2024 Heart Rhythm Society
- Holter ECG, Mortality, Nonsustained ventricular tachycardia, Premature ventricular complexes, Prognosis, Sex differences, Ventricular arrythmia
Research areas
ID: 399239137