Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults: The cardiovascular health study

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults : The cardiovascular health study. / Cronjé, Héléne T.; Liu, Xiaojuan; Odden, Michelle C.; Moseholm, Kristine F.; Seshadri, Sudha; Satizabal, Claudia L.; Lopez, Oscar L.; Bis, Joshua C.; Djoussé, Luc; Fohner, Alison E.; Psaty, Bruce M.; Tracy, Russell P.; Longstreth, W. T.; Jensen, Majken K.; Mukamal, Kenneth J.

In: Alzheimer's and Dementia, Vol. 19, No. 12, 2023, p. 5672-5680.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Cronjé, HT, Liu, X, Odden, MC, Moseholm, KF, Seshadri, S, Satizabal, CL, Lopez, OL, Bis, JC, Djoussé, L, Fohner, AE, Psaty, BM, Tracy, RP, Longstreth, WT, Jensen, MK & Mukamal, KJ 2023, 'Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults: The cardiovascular health study', Alzheimer's and Dementia, vol. 19, no. 12, pp. 5672-5680. https://doi.org/10.1002/alz.13367

APA

Cronjé, H. T., Liu, X., Odden, M. C., Moseholm, K. F., Seshadri, S., Satizabal, C. L., Lopez, O. L., Bis, J. C., Djoussé, L., Fohner, A. E., Psaty, B. M., Tracy, R. P., Longstreth, W. T., Jensen, M. K., & Mukamal, K. J. (2023). Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults: The cardiovascular health study. Alzheimer's and Dementia, 19(12), 5672-5680. https://doi.org/10.1002/alz.13367

Vancouver

Cronjé HT, Liu X, Odden MC, Moseholm KF, Seshadri S, Satizabal CL et al. Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults: The cardiovascular health study. Alzheimer's and Dementia. 2023;19(12):5672-5680. https://doi.org/10.1002/alz.13367

Author

Cronjé, Héléne T. ; Liu, Xiaojuan ; Odden, Michelle C. ; Moseholm, Kristine F. ; Seshadri, Sudha ; Satizabal, Claudia L. ; Lopez, Oscar L. ; Bis, Joshua C. ; Djoussé, Luc ; Fohner, Alison E. ; Psaty, Bruce M. ; Tracy, Russell P. ; Longstreth, W. T. ; Jensen, Majken K. ; Mukamal, Kenneth J. / Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults : The cardiovascular health study. In: Alzheimer's and Dementia. 2023 ; Vol. 19, No. 12. pp. 5672-5680.

Bibtex

@article{afb6c2fbb85b42d0b1a826717d5945ef,
title = "Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults: The cardiovascular health study",
abstract = "INTRODUCTION: Circulating neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) have been independently associated with dementia risk. Their additive association, and their associations with dementia-specific mortality, have not been investigated. METHODS: We associated serum NfL, GFAP, total tau, and ubiquitin carboxyl-terminal hydrolase-L1, measured in 1712 dementia-free adults, with 19-year incident dementia and dementia-specific mortality risk, and with 3-year cognitive decline. RESULTS: In adjusted models, being in the highest versus lowest tertile of NfL or GFAP associated with a hazard ratio (HR) of 1.49 (1.20–1.84) and 1.38 (1.15–1.66) for incident dementia, and 2.87 (1.79–4.61) and 2.76 (1.73–4.40) for dementia-specific mortality. Joint third versus first tertile exposure further increased risk; HR = 2.06 (1.60–2.67) and 9.22 (4.48–18.9). NfL was independently associated with accelerated cognitive decline. DISCUSSION: Circulating NfL and GFAP may, independently and jointly, provide useful clinical insight regarding dementia risk and prognosis.",
keywords = "blood-based biomarkers, cognition, dementia, longitudinal, Modified Mini-Mental State Examination, mortality, risk factor, serum",
author = "Cronj{\'e}, {H{\'e}l{\'e}ne T.} and Xiaojuan Liu and Odden, {Michelle C.} and Moseholm, {Kristine F.} and Sudha Seshadri and Satizabal, {Claudia L.} and Lopez, {Oscar L.} and Bis, {Joshua C.} and Luc Djouss{\'e} and Fohner, {Alison E.} and Psaty, {Bruce M.} and Tracy, {Russell P.} and Longstreth, {W. T.} and Jensen, {Majken K.} and Mukamal, {Kenneth J.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",
year = "2023",
doi = "10.1002/alz.13367",
language = "English",
volume = "19",
pages = "5672--5680",
journal = "Alzheimer's & Dementia",
issn = "1552-5260",
publisher = "Elsevier",
number = "12",

}

RIS

TY - JOUR

T1 - Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults

T2 - The cardiovascular health study

AU - Cronjé, Héléne T.

AU - Liu, Xiaojuan

AU - Odden, Michelle C.

AU - Moseholm, Kristine F.

AU - Seshadri, Sudha

AU - Satizabal, Claudia L.

AU - Lopez, Oscar L.

AU - Bis, Joshua C.

AU - Djoussé, Luc

AU - Fohner, Alison E.

AU - Psaty, Bruce M.

AU - Tracy, Russell P.

AU - Longstreth, W. T.

AU - Jensen, Majken K.

AU - Mukamal, Kenneth J.

N1 - Publisher Copyright: © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

PY - 2023

Y1 - 2023

N2 - INTRODUCTION: Circulating neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) have been independently associated with dementia risk. Their additive association, and their associations with dementia-specific mortality, have not been investigated. METHODS: We associated serum NfL, GFAP, total tau, and ubiquitin carboxyl-terminal hydrolase-L1, measured in 1712 dementia-free adults, with 19-year incident dementia and dementia-specific mortality risk, and with 3-year cognitive decline. RESULTS: In adjusted models, being in the highest versus lowest tertile of NfL or GFAP associated with a hazard ratio (HR) of 1.49 (1.20–1.84) and 1.38 (1.15–1.66) for incident dementia, and 2.87 (1.79–4.61) and 2.76 (1.73–4.40) for dementia-specific mortality. Joint third versus first tertile exposure further increased risk; HR = 2.06 (1.60–2.67) and 9.22 (4.48–18.9). NfL was independently associated with accelerated cognitive decline. DISCUSSION: Circulating NfL and GFAP may, independently and jointly, provide useful clinical insight regarding dementia risk and prognosis.

AB - INTRODUCTION: Circulating neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) have been independently associated with dementia risk. Their additive association, and their associations with dementia-specific mortality, have not been investigated. METHODS: We associated serum NfL, GFAP, total tau, and ubiquitin carboxyl-terminal hydrolase-L1, measured in 1712 dementia-free adults, with 19-year incident dementia and dementia-specific mortality risk, and with 3-year cognitive decline. RESULTS: In adjusted models, being in the highest versus lowest tertile of NfL or GFAP associated with a hazard ratio (HR) of 1.49 (1.20–1.84) and 1.38 (1.15–1.66) for incident dementia, and 2.87 (1.79–4.61) and 2.76 (1.73–4.40) for dementia-specific mortality. Joint third versus first tertile exposure further increased risk; HR = 2.06 (1.60–2.67) and 9.22 (4.48–18.9). NfL was independently associated with accelerated cognitive decline. DISCUSSION: Circulating NfL and GFAP may, independently and jointly, provide useful clinical insight regarding dementia risk and prognosis.

KW - blood-based biomarkers

KW - cognition

KW - dementia

KW - longitudinal

KW - Modified Mini-Mental State Examination

KW - mortality

KW - risk factor

KW - serum

U2 - 10.1002/alz.13367

DO - 10.1002/alz.13367

M3 - Journal article

C2 - 37392405

AN - SCOPUS:85164166520

VL - 19

SP - 5672

EP - 5680

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

SN - 1552-5260

IS - 12

ER -

ID: 359850679