Serum neurofilament light levels are correlated to long-term neurocognitive outcome measures after cardiac arrest
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Serum neurofilament light levels are correlated to long-term neurocognitive outcome measures after cardiac arrest. / Nordstrom, Erik Blennow; Lilja, Gisela; Ullen, Susann; Blennow, Kaj; Friberg, Hans; Hassager, Christian; Kjaergaard, Jesper; Mattsson-Carlgren, Niklas; Moseby-Knappe, Marion; Nielsen, Niklas; Vestberg, Susanna; Zetterberg, Henrik; Cronberg, Tobias.
In: Brain Injury, Vol. 36, No. 6, 2022, p. 800-809.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Serum neurofilament light levels are correlated to long-term neurocognitive outcome measures after cardiac arrest
AU - Nordstrom, Erik Blennow
AU - Lilja, Gisela
AU - Ullen, Susann
AU - Blennow, Kaj
AU - Friberg, Hans
AU - Hassager, Christian
AU - Kjaergaard, Jesper
AU - Mattsson-Carlgren, Niklas
AU - Moseby-Knappe, Marion
AU - Nielsen, Niklas
AU - Vestberg, Susanna
AU - Zetterberg, Henrik
AU - Cronberg, Tobias
PY - 2022
Y1 - 2022
N2 - Objective To explore associations between four methods assessing long-term neurocognitive outcome after out-of-hospital cardiac arrest and early hypoxic-ischemic neuronal brain injury assessed by the biomarker serum neurofilament light (NFL), and to compare the agreement for the outcome methods. Methods An explorative post-hoc study was conducted on survivor data from the international Target Temperature Management after Out-of-hospital Cardiac Arrest trial, investigating serum NFL sampled 48/72-hours post-arrest and neurocognitive outcome 6 months post-arrest. Results Among the long-term surviving participants (N = 457), serum NFL (n = 384) was associated to all outcome instruments, also when controlling for demographic and cardiovascular risk factors. Associations between NFL and the patient-reported Two Simple Questions (TSQ) were however attenuated when adjusting for vitality and mental health. NFL predicted results on the outcome instruments to varying degrees, with an excellent area under the curve for the clinician-report Cerebral Performance Category (CPC 1-2: 0.90). Most participants were classified as CPC 1 (79%). Outcome instrument correlations ranged from small (Mini-Mental State Examination [MMSE]-TSQ) to strong (CPC-MMSE). Conclusions The clinician-reported CPC was mostly related to hypoxic-ischemic brain injury, but with a ceiling effect. These results may be useful when selecting methods and instruments for clinical follow-up models.
AB - Objective To explore associations between four methods assessing long-term neurocognitive outcome after out-of-hospital cardiac arrest and early hypoxic-ischemic neuronal brain injury assessed by the biomarker serum neurofilament light (NFL), and to compare the agreement for the outcome methods. Methods An explorative post-hoc study was conducted on survivor data from the international Target Temperature Management after Out-of-hospital Cardiac Arrest trial, investigating serum NFL sampled 48/72-hours post-arrest and neurocognitive outcome 6 months post-arrest. Results Among the long-term surviving participants (N = 457), serum NFL (n = 384) was associated to all outcome instruments, also when controlling for demographic and cardiovascular risk factors. Associations between NFL and the patient-reported Two Simple Questions (TSQ) were however attenuated when adjusting for vitality and mental health. NFL predicted results on the outcome instruments to varying degrees, with an excellent area under the curve for the clinician-report Cerebral Performance Category (CPC 1-2: 0.90). Most participants were classified as CPC 1 (79%). Outcome instrument correlations ranged from small (Mini-Mental State Examination [MMSE]-TSQ) to strong (CPC-MMSE). Conclusions The clinician-reported CPC was mostly related to hypoxic-ischemic brain injury, but with a ceiling effect. These results may be useful when selecting methods and instruments for clinical follow-up models.
KW - Hypoxic-ischemic encephalopathy
KW - heart arrest
KW - cognitive impairment
KW - biomarker
KW - cardiovascular disease
KW - TARGETED TEMPERATURE MANAGEMENT
KW - QUALITY-OF-LIFE
KW - SUBJECTIVE COGNITIVE COMPLAINTS
KW - MENTAL-STATE-EXAMINATION
KW - SIMPLE QUESTIONS
KW - 33-DEGREES-C
KW - RESUSCITATION
KW - 36-DEGREES-C
KW - EPIDEMIOLOGY
KW - SURVIVORS
U2 - 10.1080/02699052.2022.2048693
DO - 10.1080/02699052.2022.2048693
M3 - Journal article
C2 - 35253570
VL - 36
SP - 800
EP - 809
JO - Brain Injury
JF - Brain Injury
SN - 0269-9052
IS - 6
ER -
ID: 308117453