Serum alpha-fetoprotein and alcohol consumption
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Serum alpha-fetoprotein and alcohol consumption. / Christiansen, Michael; Andersen, Jens Rikardt; Tørning, J.; Overgård, Ove; Jensen, S P; Magid, E; Nørgaard-Pedersen, B.
In: Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 54, No. 3, 1994, p. 215-220.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Serum alpha-fetoprotein and alcohol consumption
AU - Christiansen, Michael
AU - Andersen, Jens Rikardt
AU - Tørning, J.
AU - Overgård, Ove
AU - Jensen, S P
AU - Magid, E
AU - Nørgaard-Pedersen, B
N1 - (Eksterne)
PY - 1994
Y1 - 1994
N2 - Fifty-nine persons, 23 chronic alcoholics and 36 normal healthy persons with a well described alcohol consumption, had the serum concentration of alpha-fetoprotein determined by a sensitive monoclonal immunofluorescent assay. A significant elevation in S-AFP was found in alcoholics, median 4.1 kIU/1 as compared to 3.0kIU/l in near-abstainers (<12g ethanol per day) (p<0.02). This difference was not explained by differences in age. S-AFP correlated positively with age (p = 0.01). In non-alcoholics a borderline significant correlation with S-AFP was found with average daily alcohol consumption (self-reported) (p = 0.09) and a significant correlation with the serum concentration of carbohydrate-deficient transferrin (S-CDT) (p = 0.004). In 11 alcoholics 2 months of abstention from alcohol was accompanied by a median reduction of 21% in S-AFP (p < 10-5). In alcoholics, but not in social drinkers, S-AFP correlated with S-ASAT (p = 0.004). The increase of S-AFP with alcohol consumption may reflect reversible alcohol-induced liver affection.
AB - Fifty-nine persons, 23 chronic alcoholics and 36 normal healthy persons with a well described alcohol consumption, had the serum concentration of alpha-fetoprotein determined by a sensitive monoclonal immunofluorescent assay. A significant elevation in S-AFP was found in alcoholics, median 4.1 kIU/1 as compared to 3.0kIU/l in near-abstainers (<12g ethanol per day) (p<0.02). This difference was not explained by differences in age. S-AFP correlated positively with age (p = 0.01). In non-alcoholics a borderline significant correlation with S-AFP was found with average daily alcohol consumption (self-reported) (p = 0.09) and a significant correlation with the serum concentration of carbohydrate-deficient transferrin (S-CDT) (p = 0.004). In 11 alcoholics 2 months of abstention from alcohol was accompanied by a median reduction of 21% in S-AFP (p < 10-5). In alcoholics, but not in social drinkers, S-AFP correlated with S-ASAT (p = 0.004). The increase of S-AFP with alcohol consumption may reflect reversible alcohol-induced liver affection.
KW - Alcohol
KW - Alcoholic liver disease
KW - Alpha-fetoprotein
KW - Carbohydrate-deficient transferrin
UR - http://www.scopus.com/inward/record.url?scp=0027930189&partnerID=8YFLogxK
U2 - 10.3109/00365519409088427
DO - 10.3109/00365519409088427
M3 - Journal article
C2 - 7518611
AN - SCOPUS:0027930189
VL - 54
SP - 215
EP - 220
JO - Scandinavian Journal of Clinical and Laboratory Investigation. Supplement
JF - Scandinavian Journal of Clinical and Laboratory Investigation. Supplement
SN - 0085-591X
IS - 3
ER -
ID: 251990115