Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-infected Individuals
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Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-infected Individuals. / Salado-Rasmussen, Kirsten; Hoffmann, Steen; Cowan, Susan; Jensen, Jørgen Skov; Benfield, Thomas; Gerstoft, Jan; Katzenstein, Terese Lea.
In: Acta Dermatovenereologica, Vol. 96, No. 6, 2016, p. 807-811.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-infected Individuals
AU - Salado-Rasmussen, Kirsten
AU - Hoffmann, Steen
AU - Cowan, Susan
AU - Jensen, Jørgen Skov
AU - Benfield, Thomas
AU - Gerstoft, Jan
AU - Katzenstein, Terese Lea
PY - 2016
Y1 - 2016
N2 - Serological response to treatment of syphilis with orally administered doxycycline or intramuscularly administered penicillin was assessed in patients with concurrent HIV. All HIV-infected individuals diagnosed with syphilis attending 3 hospitals in Copenhagen, Denmark were included. Odds ratios (ORs) with 95% confidence intervals (CI) associated with serological outcome were modelled using propensity-score-adjusted logistic regression analysis. In total, 202 cases were treated with doxycycline or intramuscular penicillin. At 12 months, serological failure was observed in 12 cases (15%) treated with doxycycline and in 8 cases (17%) treated with penicillin (OR 0.78 (95% CI 0.16-3.88), p = 0.76). The serological cure rate at 12 months was highest in patients with primary syphilis (100%), followed by patients with secondary (89%), early latent (71%) and late latent (67%) syphilis (p = 0.006). In conclusion, this study provides evidence for the use of doxycycline as a treatment option when treating a HIV-infected population for syphilis.
AB - Serological response to treatment of syphilis with orally administered doxycycline or intramuscularly administered penicillin was assessed in patients with concurrent HIV. All HIV-infected individuals diagnosed with syphilis attending 3 hospitals in Copenhagen, Denmark were included. Odds ratios (ORs) with 95% confidence intervals (CI) associated with serological outcome were modelled using propensity-score-adjusted logistic regression analysis. In total, 202 cases were treated with doxycycline or intramuscular penicillin. At 12 months, serological failure was observed in 12 cases (15%) treated with doxycycline and in 8 cases (17%) treated with penicillin (OR 0.78 (95% CI 0.16-3.88), p = 0.76). The serological cure rate at 12 months was highest in patients with primary syphilis (100%), followed by patients with secondary (89%), early latent (71%) and late latent (67%) syphilis (p = 0.006). In conclusion, this study provides evidence for the use of doxycycline as a treatment option when treating a HIV-infected population for syphilis.
KW - Administration, Oral
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Anti-Bacterial Agents
KW - Denmark
KW - Doxycycline
KW - Female
KW - HIV Seropositivity
KW - Humans
KW - Injections
KW - Male
KW - Middle Aged
KW - Penicillins
KW - Retrospective Studies
KW - Syphilis
KW - Treatment Outcome
KW - Comparative Study
U2 - 10.2340/00015555-2289
DO - 10.2340/00015555-2289
M3 - Journal article
C2 - 26568359
VL - 96
SP - 807
EP - 811
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
IS - 6
ER -
ID: 173675418