Selective suppression of chemokine receptor CXCR3 expression by interferon-beta1a in multiple sclerosis
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Selective suppression of chemokine receptor CXCR3 expression by interferon-beta1a in multiple sclerosis. / Sørensen, Torben Lykke; Sellebjerg, F.
In: Multiple Sclerosis, Vol. 8, No. 2, 04.2002, p. 104-7.Research output: Contribution to journal › Journal article › Research
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TY - JOUR
T1 - Selective suppression of chemokine receptor CXCR3 expression by interferon-beta1a in multiple sclerosis
AU - Sørensen, Torben Lykke
AU - Sellebjerg, F
PY - 2002/4
Y1 - 2002/4
N2 - We studied the expression of chemokine receptors CCR1, CCR2, CCR3, CCR5, and CXCR3 on CD4 and CD8 positive T cells, and on CD14 positive monocytes in blood from 10 patients with relapsing-remitting multiple sclerosis (MS) at initiation of interferon (IFN)-beta treatment, after 1 month and after 3 months of treatment. It was found that the expression of CXCR3 on CD4+ and CD8+ T cells was significantly reduced after 3 months of treatment. The expression of other receptors was unaltered. Since CXCR3 cells are enriched in cerebrospinal fluid (CSF), and are detected in lesion material in MS this may represent an important mode of action of interferon-beta in MS.
AB - We studied the expression of chemokine receptors CCR1, CCR2, CCR3, CCR5, and CXCR3 on CD4 and CD8 positive T cells, and on CD14 positive monocytes in blood from 10 patients with relapsing-remitting multiple sclerosis (MS) at initiation of interferon (IFN)-beta treatment, after 1 month and after 3 months of treatment. It was found that the expression of CXCR3 on CD4+ and CD8+ T cells was significantly reduced after 3 months of treatment. The expression of other receptors was unaltered. Since CXCR3 cells are enriched in cerebrospinal fluid (CSF), and are detected in lesion material in MS this may represent an important mode of action of interferon-beta in MS.
KW - Adult
KW - CD4-Positive T-Lymphocytes
KW - CD8-Positive T-Lymphocytes
KW - Disability Evaluation
KW - Down-Regulation
KW - Female
KW - Humans
KW - Immunologic Factors
KW - Interferon-beta
KW - Male
KW - Middle Aged
KW - Multiple Sclerosis, Relapsing-Remitting
KW - Receptors, CXCR3
KW - Receptors, Chemokine
KW - T-Lymphocyte Subsets
KW - Time Factors
M3 - Journal article
C2 - 11990865
VL - 8
SP - 104
EP - 107
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
SN - 1352-4585
IS - 2
ER -
ID: 111410768