Salidroside promotes healthy longevity by interfering with HSP90 activity
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Salidroside promotes healthy longevity by interfering with HSP90 activity. / Zhang, Jianfei; Li, Zhiquan; Song, Jiangbo; Zhou, Lei; Chen, Xin; Ge, Wen; Dong, Tianyi; Luo, Yuxin; Mao, Ting; Li, Zheng; Tan, Duan; Rasmussen, Lene Juel; Bohr, Vilhelm A.; Tong, Xiaoling; Dai, Fangyin.
In: GeroScience, Vol. 46, 2024, p. 1641–1655.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Salidroside promotes healthy longevity by interfering with HSP90 activity
AU - Zhang, Jianfei
AU - Li, Zhiquan
AU - Song, Jiangbo
AU - Zhou, Lei
AU - Chen, Xin
AU - Ge, Wen
AU - Dong, Tianyi
AU - Luo, Yuxin
AU - Mao, Ting
AU - Li, Zheng
AU - Tan, Duan
AU - Rasmussen, Lene Juel
AU - Bohr, Vilhelm A.
AU - Tong, Xiaoling
AU - Dai, Fangyin
N1 - Publisher Copyright: © 2023, The Author(s), under exclusive licence to American Aging Association.
PY - 2024
Y1 - 2024
N2 - Aging is a risk factor for human health and quality of life. Screening and development of novel supplements and medications to combat aging and delay the incidence of age-related diseases are of great significance. In this study, salidroside (SA), a primary natural small molecule from Rhodiola rosea, was investigated regarding its effects on life and healthspan and the underlying molecular mechanism(s) of anti-aging and antioxidation. Our results showed that SA effectively prolonged lifespan and exhibited anti-aging and antioxidative properties. Computer-assisted methods, label-free interaction analysis, and in vitro assays showed that SA directly bound heat shock protein 90 (HSP90). Furthermore, SA significantly inhibited the ATPase activity of HSP90, affecting the interaction between HSP90 and its interacting proteins and the expression of downstream genes to regulate lifespan and the oxidative stress response. Our findings provided new insights into the pharmacological properties of SA across multiple species and its potential as an anti-aging drug.
AB - Aging is a risk factor for human health and quality of life. Screening and development of novel supplements and medications to combat aging and delay the incidence of age-related diseases are of great significance. In this study, salidroside (SA), a primary natural small molecule from Rhodiola rosea, was investigated regarding its effects on life and healthspan and the underlying molecular mechanism(s) of anti-aging and antioxidation. Our results showed that SA effectively prolonged lifespan and exhibited anti-aging and antioxidative properties. Computer-assisted methods, label-free interaction analysis, and in vitro assays showed that SA directly bound heat shock protein 90 (HSP90). Furthermore, SA significantly inhibited the ATPase activity of HSP90, affecting the interaction between HSP90 and its interacting proteins and the expression of downstream genes to regulate lifespan and the oxidative stress response. Our findings provided new insights into the pharmacological properties of SA across multiple species and its potential as an anti-aging drug.
KW - Aging
KW - Drug target identification
KW - HSP90
KW - Lifespan
KW - Rhodiola rosea
KW - Salidroside
U2 - 10.1007/s11357-023-00921-3
DO - 10.1007/s11357-023-00921-3
M3 - Journal article
C2 - 37713088
AN - SCOPUS:85171266246
VL - 46
SP - 1641
EP - 1655
JO - GeroScience
JF - GeroScience
SN - 0161-9152
ER -
ID: 370797383