Role of protein dynamics in transmembrane receptor signalling

Research output: Contribution to journal › Review › Research › peer-review

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Role of protein dynamics in transmembrane receptor signalling. / Wang, Yong; Bugge, Katrine Østergaard; Kragelund, Birthe Brandt; Lindorff-Larsen, Kresten.

In: Current Opinion in Structural Biology, Vol. 48, 2018, p. 74-82.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Wang, Y, Bugge, KØ, Kragelund, BB & Lindorff-Larsen, K 2018, 'Role of protein dynamics in transmembrane receptor signalling', Current Opinion in Structural Biology, vol. 48, pp. 74-82. https://doi.org/10.1016/j.sbi.2017.10.017

APA

Wang, Y., Bugge, K. Ø., Kragelund, B. B., & Lindorff-Larsen, K. (2018). Role of protein dynamics in transmembrane receptor signalling. Current Opinion in Structural Biology, 48, 74-82. https://doi.org/10.1016/j.sbi.2017.10.017

Vancouver

Wang Y, Bugge KØ, Kragelund BB, Lindorff-Larsen K. Role of protein dynamics in transmembrane receptor signalling. Current Opinion in Structural Biology. 2018;48:74-82. https://doi.org/10.1016/j.sbi.2017.10.017

Author

Wang, Yong ; Bugge, Katrine Østergaard ; Kragelund, Birthe Brandt ; Lindorff-Larsen, Kresten. / Role of protein dynamics in transmembrane receptor signalling. In: Current Opinion in Structural Biology. 2018 ; Vol. 48. pp. 74-82.

Bibtex

@article{ce71a62664c248688c8d44b4eae65a2f,

title = "Role of protein dynamics in transmembrane receptor signalling",

abstract = "Cells are dependent on transmembrane receptors to communicate and transform chemical and physical signals into intracellular responses. Because receptors transport 'information', conformational changes and protein dynamics play a key mechanistic role. We here review examples where experiment and computation have been used to study receptor dynamics. Recent studies on three distinct classes of receptors (G-protein coupled receptors, ligand-gated ion-channels and single-pass receptors) are highlighted to show that conformational changes across a range of time-scales and length-scales are central to function. Because the receptors function in a heterogeneous environment and need to be able to switch between distinct functional states, they may be particularly sensitive to small perturbations that complicate studies linking dynamics to function.",

keywords = "Journal Article, Review",

author = "Yong Wang and Bugge, {Katrine {\O}stergaard} and Kragelund, {Birthe Brandt} and Kresten Lindorff-Larsen",

year = "2018",

doi = "10.1016/j.sbi.2017.10.017",

language = "English",

volume = "48",

pages = "74--82",

journal = "Current Opinion in Structural Biology",

issn = "0959-440X",

publisher = "Elsevier Ltd. * Current Opinion Journals",

}

RIS

TY - JOUR

T1 - Role of protein dynamics in transmembrane receptor signalling

AU - Wang, Yong

AU - Bugge, Katrine Østergaard

AU - Kragelund, Birthe Brandt

AU - Lindorff-Larsen, Kresten

PY - 2018

Y1 - 2018

N2 - Cells are dependent on transmembrane receptors to communicate and transform chemical and physical signals into intracellular responses. Because receptors transport 'information', conformational changes and protein dynamics play a key mechanistic role. We here review examples where experiment and computation have been used to study receptor dynamics. Recent studies on three distinct classes of receptors (G-protein coupled receptors, ligand-gated ion-channels and single-pass receptors) are highlighted to show that conformational changes across a range of time-scales and length-scales are central to function. Because the receptors function in a heterogeneous environment and need to be able to switch between distinct functional states, they may be particularly sensitive to small perturbations that complicate studies linking dynamics to function.

AB - Cells are dependent on transmembrane receptors to communicate and transform chemical and physical signals into intracellular responses. Because receptors transport 'information', conformational changes and protein dynamics play a key mechanistic role. We here review examples where experiment and computation have been used to study receptor dynamics. Recent studies on three distinct classes of receptors (G-protein coupled receptors, ligand-gated ion-channels and single-pass receptors) are highlighted to show that conformational changes across a range of time-scales and length-scales are central to function. Because the receptors function in a heterogeneous environment and need to be able to switch between distinct functional states, they may be particularly sensitive to small perturbations that complicate studies linking dynamics to function.

KW - Journal Article

KW - Review

U2 - 10.1016/j.sbi.2017.10.017

DO - 10.1016/j.sbi.2017.10.017

M3 - Review

C2 - 29136528

VL - 48

SP - 74

EP - 82

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

SN - 0959-440X

ER -

ID: 188260770

Forskning