Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors
Research output: Contribution to journal › Journal article › Research › peer-review
G protein-coupled receptors are divided into three classes (A, B and C) based on homology of their seven transmembrane domains. Class C is the smallest class with 22 human receptor subtypes including eight metabotropic glutamate (mGlu1-8) receptors, two GABAB receptors (GABAB1 and GABAB2), three taste receptors (T1R1-3), one calcium-sensing (CaS) receptor, one GPCR, class C, group 6, subtype A (GPRC6) receptor, and seven orphan receptors. G protein-coupled receptors undergo a number of post-translational modifications, which regulate their structure, function and/or pharmacology. Here, we review the existence of post-translational modifications in class C G protein-coupled receptors and their regulatory roles, with particular focus on glycosylation, phosphorylation, ubiquitination, SUMOylation, disulphide bonding and lipidation.
Original language | English |
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Journal | European Journal of Pharmacology |
Volume | 763 |
Pages (from-to) | 233-240 |
Number of pages | 8 |
ISSN | 0014-2999 |
DOIs | |
Publication status | Published - 2015 |
ID: 141520864