Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors

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Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors. / Nørskov-Lauritsen, Lenea; Bräuner-Osborne, Hans.

In: European Journal of Pharmacology, Vol. 763, 2015, p. 233-240.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nørskov-Lauritsen, L & Bräuner-Osborne, H 2015, 'Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors', European Journal of Pharmacology, vol. 763, pp. 233-240. https://doi.org/10.1016/j.ejphar.2015.05.015

APA

Nørskov-Lauritsen, L., & Bräuner-Osborne, H. (2015). Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors. European Journal of Pharmacology, 763, 233-240. https://doi.org/10.1016/j.ejphar.2015.05.015

Vancouver

Nørskov-Lauritsen L, Bräuner-Osborne H. Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors. European Journal of Pharmacology. 2015;763:233-240. https://doi.org/10.1016/j.ejphar.2015.05.015

Author

Nørskov-Lauritsen, Lenea ; Bräuner-Osborne, Hans. / Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors. In: European Journal of Pharmacology. 2015 ; Vol. 763. pp. 233-240.

Bibtex

@article{5ce68174216b44d393e51abbe2c5711e,

title = "Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors",

abstract = "G protein-coupled receptors are divided into three classes (A, B and C) based on homology of their seven transmembrane domains. Class C is the smallest class with 22 human receptor subtypes including eight metabotropic glutamate (mGlu1-8) receptors, two GABAB receptors (GABAB1 and GABAB2), three taste receptors (T1R1-3), one calcium-sensing (CaS) receptor, one GPCR, class C, group 6, subtype A (GPRC6) receptor, and seven orphan receptors. G protein-coupled receptors undergo a number of post-translational modifications, which regulate their structure, function and/or pharmacology. Here, we review the existence of post-translational modifications in class C G protein-coupled receptors and their regulatory roles, with particular focus on glycosylation, phosphorylation, ubiquitination, SUMOylation, disulphide bonding and lipidation.",

author = "Lenea N{\o}rskov-Lauritsen and Hans Br{\"a}uner-Osborne",

note = "Copyright {\textcopyright} 2015. Published by Elsevier B.V.",

year = "2015",

doi = "10.1016/j.ejphar.2015.05.015",

language = "English",

volume = "763",

pages = "233--240",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors

AU - Nørskov-Lauritsen, Lenea

AU - Bräuner-Osborne, Hans

PY - 2015

Y1 - 2015

N2 - G protein-coupled receptors are divided into three classes (A, B and C) based on homology of their seven transmembrane domains. Class C is the smallest class with 22 human receptor subtypes including eight metabotropic glutamate (mGlu1-8) receptors, two GABAB receptors (GABAB1 and GABAB2), three taste receptors (T1R1-3), one calcium-sensing (CaS) receptor, one GPCR, class C, group 6, subtype A (GPRC6) receptor, and seven orphan receptors. G protein-coupled receptors undergo a number of post-translational modifications, which regulate their structure, function and/or pharmacology. Here, we review the existence of post-translational modifications in class C G protein-coupled receptors and their regulatory roles, with particular focus on glycosylation, phosphorylation, ubiquitination, SUMOylation, disulphide bonding and lipidation.

AB - G protein-coupled receptors are divided into three classes (A, B and C) based on homology of their seven transmembrane domains. Class C is the smallest class with 22 human receptor subtypes including eight metabotropic glutamate (mGlu1-8) receptors, two GABAB receptors (GABAB1 and GABAB2), three taste receptors (T1R1-3), one calcium-sensing (CaS) receptor, one GPCR, class C, group 6, subtype A (GPRC6) receptor, and seven orphan receptors. G protein-coupled receptors undergo a number of post-translational modifications, which regulate their structure, function and/or pharmacology. Here, we review the existence of post-translational modifications in class C G protein-coupled receptors and their regulatory roles, with particular focus on glycosylation, phosphorylation, ubiquitination, SUMOylation, disulphide bonding and lipidation.

U2 - 10.1016/j.ejphar.2015.05.015

DO - 10.1016/j.ejphar.2015.05.015

M3 - Journal article

C2 - 25981296

VL - 763

SP - 233

EP - 240

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

ER -

ID: 141520864

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