Risk factors for fatigue and impaired function eight months after hospital admission with COVID-19
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Risk factors for fatigue and impaired function eight months after hospital admission with COVID-19. / Schouborg, Louise Brinth; Molsted, Stig; Lendorf, Maria Elisabeth; Hegelund, Maria Hein; Ryrsø, Camilla Kock; Sommer, Dorthe Holm; Kolte, Lilian; Nolsöe, Rúna L; Pedersen, Thomas Ingemann; Harboe, Zitta Barella; Browatzki, Andrea; Brandi, Lisbeth; Krog, Sebastian Moretto; Bestle, Morten H; Jørgensen, Inger Merete; Jensen, Tomas Østergaard; Fischer, Thea K; Pedersen-Bjergaard, Ulrik; Lindegaard, Birgitte.
In: Danish Medical Journal, Vol. 69, No. 4, A08210633, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Risk factors for fatigue and impaired function eight months after hospital admission with COVID-19
AU - Schouborg, Louise Brinth
AU - Molsted, Stig
AU - Lendorf, Maria Elisabeth
AU - Hegelund, Maria Hein
AU - Ryrsø, Camilla Kock
AU - Sommer, Dorthe Holm
AU - Kolte, Lilian
AU - Nolsöe, Rúna L
AU - Pedersen, Thomas Ingemann
AU - Harboe, Zitta Barella
AU - Browatzki, Andrea
AU - Brandi, Lisbeth
AU - Krog, Sebastian Moretto
AU - Bestle, Morten H
AU - Jørgensen, Inger Merete
AU - Jensen, Tomas Østergaard
AU - Fischer, Thea K
AU - Pedersen-Bjergaard, Ulrik
AU - Lindegaard, Birgitte
N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
PY - 2022
Y1 - 2022
N2 - INTRODUCTION: We aimed to evaluate post-COVID-19 fatigue, change in functional capacity and health-related quality of life (HRQoL) eight months after discharge from hospital due to COVID-19.METHODS: A total of 83 patients (35 women) admitted to the Copenhagen University Hospital - North Zealand Hospital, Denmark, for COVID-19 during the period from March to June 2020 were evaluated eight months after discharge using validated questionnaires quantifying fatigue, HRQoL and post-COVID-19 functional status. Follow-up data were correlated with measures of pre-COVID-19 status (anthropometrics, comorbidities) and measures of severity of the acute infection.RESULTS: A total of 22 (65%) women and 12 (26%) men reported excessive fatigue. In all, 20 women (67%) and 17 men (37%) reported decreased physical function. Female sex was associated with fatigue. Loss of physical function was associated with pre-COVID-19 presence of heart disease and absence of lung disease. Severity of the acute COVID-19 infection was not associated with fatigue or change in functional status. Fatigue and functional status were correlated with both generic HRQoL and lung disease-specific HRQoL.CONCLUSIONS: Female sex was associated with a higher risk of fatigue eight months after hospitalisation with COVID-19 infection. Regarding loss of functional capacity after COVID-19, we found an apparently protective effect of pre-COVID-19 lung disease. Our findings underscore the urgent need for further research and the importance of evaluating those recovering from COVID-19 for symptoms of excessive fatigue and change in functional capacity irrespective of the severity of the initial infection.FUNDING: none.TRIAL REGISTRATION: not relevant.
AB - INTRODUCTION: We aimed to evaluate post-COVID-19 fatigue, change in functional capacity and health-related quality of life (HRQoL) eight months after discharge from hospital due to COVID-19.METHODS: A total of 83 patients (35 women) admitted to the Copenhagen University Hospital - North Zealand Hospital, Denmark, for COVID-19 during the period from March to June 2020 were evaluated eight months after discharge using validated questionnaires quantifying fatigue, HRQoL and post-COVID-19 functional status. Follow-up data were correlated with measures of pre-COVID-19 status (anthropometrics, comorbidities) and measures of severity of the acute infection.RESULTS: A total of 22 (65%) women and 12 (26%) men reported excessive fatigue. In all, 20 women (67%) and 17 men (37%) reported decreased physical function. Female sex was associated with fatigue. Loss of physical function was associated with pre-COVID-19 presence of heart disease and absence of lung disease. Severity of the acute COVID-19 infection was not associated with fatigue or change in functional status. Fatigue and functional status were correlated with both generic HRQoL and lung disease-specific HRQoL.CONCLUSIONS: Female sex was associated with a higher risk of fatigue eight months after hospitalisation with COVID-19 infection. Regarding loss of functional capacity after COVID-19, we found an apparently protective effect of pre-COVID-19 lung disease. Our findings underscore the urgent need for further research and the importance of evaluating those recovering from COVID-19 for symptoms of excessive fatigue and change in functional capacity irrespective of the severity of the initial infection.FUNDING: none.TRIAL REGISTRATION: not relevant.
KW - COVID-19/complications
KW - Comorbidity
KW - Fatigue/diagnosis
KW - Female
KW - Hospitalization
KW - Humans
KW - Male
KW - Physical Functional Performance
KW - Quality of Life
KW - Recovery of Function
KW - Risk Factors
KW - SARS-CoV-2
KW - Sickness Impact Profile
M3 - Journal article
C2 - 35319451
VL - 69
JO - Danish Medical Journal
JF - Danish Medical Journal
SN - 2245-1919
IS - 4
M1 - A08210633
ER -
ID: 305082521