Retinal angiographic blood flowmetry is reduced in the ocular ischaemic syndrome
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Retinal angiographic blood flowmetry is reduced in the ocular ischaemic syndrome. / Hansen, Grith Lssrkholm; Kofoed, Peter Kristian; Munch, Inger Christine; Sillesen, Henrik; Jensen, Leif Panduro; Iversen, Helle K; Larsen, Michael.
In: Danish Medical Bulletin (Online), Vol. 60, No. 10, A4716, 10.2013, p. 1-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Retinal angiographic blood flowmetry is reduced in the ocular ischaemic syndrome
AU - Hansen, Grith Lssrkholm
AU - Kofoed, Peter Kristian
AU - Munch, Inger Christine
AU - Sillesen, Henrik
AU - Jensen, Leif Panduro
AU - Iversen, Helle K
AU - Larsen, Michael
PY - 2013/10
Y1 - 2013/10
N2 - INTRODUCTION: The aim of this study was to examine the use of quantitative fluorescein angiographic analysis as a means of estimating rates of perfusion of the retina in eyes with a circulatory deficit secondary to carotid artery stenosis.MATERIAL AND METHODS: The study included 21 eyes with ocular ischaemic syndrome (OIS) and 20 control eyes from subjects with carotid artery stenosis but without signs of ocular ischaemia. Analyses of video fluorescein angiograms extracting time intervals for the time delay between specific phases of the angiogram were performed. Time delay was compared between groups and in relation to degree of carotid artery stenosis and ocular systolic blood pressure.RESULTS: Among the three flow indices of retinal perfusion (arteriovenous passage time 1 (AVP1), arteriovenous passage time 2 (AVP2) and venous filling time (VP)), those including the venous filling phase were significantly prolonged in the OIS group. Furthermore, AVP2 was delayed by 3 sec. in OIS eyes (16.6 sec. versus 13.6 sec. in controls). VP was 2.4 sec. longer in OIS eyes (11.5 sec. versus 9.1 sec.). We found a significant correlation between AVP2 and ocular perfusion pressure, but no correlation between the degree of carotid artery stenosis and any of the flow indices.CONCLUSION: In a patient population spanning a wide ocular systolic blood pressure range, angiography-based quantitative flowmetry demonstrated a difference between carotid artery stenosis patients with and without OIS and a correlation between flow and ocular perfusion pressure. While angiographic flowmetry proved effective in discriminating between groups of individuals, it can only be used to support the diagnosis of the ocular ischaemic syndrome in patients with extreme flow reduction.
AB - INTRODUCTION: The aim of this study was to examine the use of quantitative fluorescein angiographic analysis as a means of estimating rates of perfusion of the retina in eyes with a circulatory deficit secondary to carotid artery stenosis.MATERIAL AND METHODS: The study included 21 eyes with ocular ischaemic syndrome (OIS) and 20 control eyes from subjects with carotid artery stenosis but without signs of ocular ischaemia. Analyses of video fluorescein angiograms extracting time intervals for the time delay between specific phases of the angiogram were performed. Time delay was compared between groups and in relation to degree of carotid artery stenosis and ocular systolic blood pressure.RESULTS: Among the three flow indices of retinal perfusion (arteriovenous passage time 1 (AVP1), arteriovenous passage time 2 (AVP2) and venous filling time (VP)), those including the venous filling phase were significantly prolonged in the OIS group. Furthermore, AVP2 was delayed by 3 sec. in OIS eyes (16.6 sec. versus 13.6 sec. in controls). VP was 2.4 sec. longer in OIS eyes (11.5 sec. versus 9.1 sec.). We found a significant correlation between AVP2 and ocular perfusion pressure, but no correlation between the degree of carotid artery stenosis and any of the flow indices.CONCLUSION: In a patient population spanning a wide ocular systolic blood pressure range, angiography-based quantitative flowmetry demonstrated a difference between carotid artery stenosis patients with and without OIS and a correlation between flow and ocular perfusion pressure. While angiographic flowmetry proved effective in discriminating between groups of individuals, it can only be used to support the diagnosis of the ocular ischaemic syndrome in patients with extreme flow reduction.
KW - Aged
KW - Carotid Stenosis
KW - Eye
KW - Eye Diseases
KW - Female
KW - Fluorescein Angiography
KW - Humans
KW - Ischemia
KW - Male
KW - Middle Aged
KW - Regional Blood Flow
KW - Retina
KW - Rheology
KW - Syndrome
M3 - Journal article
C2 - 24083530
VL - 60
SP - 1
EP - 5
JO - Danish Medical Journal
JF - Danish Medical Journal
SN - 2245-1919
IS - 10
M1 - A4716
ER -
ID: 120843915