Restricted feeding may induce serous fat atrophy in male Göttingen minipigs

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Restricted feeding may induce serous fat atrophy in male Göttingen minipigs. / Bollen, Peter; Skydsgaard, Mikala.

In: Experimental and Toxicologic Pathology, Vol. 57, No. 5-6, 2006, p. 347-349.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bollen, P & Skydsgaard, M 2006, 'Restricted feeding may induce serous fat atrophy in male Göttingen minipigs', Experimental and Toxicologic Pathology, vol. 57, no. 5-6, pp. 347-349. https://doi.org/10.1016/j.etp.2006.03.005

APA

Bollen, P., & Skydsgaard, M. (2006). Restricted feeding may induce serous fat atrophy in male Göttingen minipigs. Experimental and Toxicologic Pathology, 57(5-6), 347-349. https://doi.org/10.1016/j.etp.2006.03.005

Vancouver

Bollen P, Skydsgaard M. Restricted feeding may induce serous fat atrophy in male Göttingen minipigs. Experimental and Toxicologic Pathology. 2006;57(5-6):347-349. https://doi.org/10.1016/j.etp.2006.03.005

Author

Bollen, Peter ; Skydsgaard, Mikala. / Restricted feeding may induce serous fat atrophy in male Göttingen minipigs. In: Experimental and Toxicologic Pathology. 2006 ; Vol. 57, No. 5-6. pp. 347-349.

Bibtex

@article{7763413144e24484ad2297b5992966dc,
title = "Restricted feeding may induce serous fat atrophy in male G{\"o}ttingen minipigs",
abstract = "Serous atrophy of the fatty tissue of bone marrow is occasionally seen in minipigs. It is not associated with compound toxicity, as it has been observed in both dosing and healthy control groups in toxicity studies, but the etiology and pathogenesis are unknown. However, a nutritional factor is suspected, since minipigs are generally diet restricted. In order to investigate this, newly weaned minipigs were fed different amounts of feed for nine months, after which the bone marrow was evaluated. Serous atrophy was observed in diet-restricted male minipigs fed on a diet based on the nutrient requirements of production pigs, but not in males fed on a diet specially designed for minipigs, at similarly restricted levels. No serous atrophy was observed in females. It was concluded that nutrient requirements of production pigs are not necessarily suitable for minipigs, as a diet based on these nutrient requirements caused total depletion of perirenal fat depots, as well as serous atrophy of the fatty tissue of bone marrow in male G{\"o}ttingen minipigs at a restricted feeding level.",
keywords = "Adipose Tissue/pathology, Animal Feed/analysis, Animals, Atrophy, Body Weight/physiology, Bone Marrow/pathology, Female, Food Deprivation, Male, Sex Factors, Specific Pathogen-Free Organisms, Swine, Swine, Miniature",
author = "Peter Bollen and Mikala Skydsgaard",
year = "2006",
doi = "10.1016/j.etp.2006.03.005",
language = "English",
volume = "57",
pages = "347--349",
journal = "Experimental and Toxicologic Pathology",
issn = "0940-2993",
publisher = "Elsevier GmbH - Urban und Fischer",
number = "5-6",

}

RIS

TY - JOUR

T1 - Restricted feeding may induce serous fat atrophy in male Göttingen minipigs

AU - Bollen, Peter

AU - Skydsgaard, Mikala

PY - 2006

Y1 - 2006

N2 - Serous atrophy of the fatty tissue of bone marrow is occasionally seen in minipigs. It is not associated with compound toxicity, as it has been observed in both dosing and healthy control groups in toxicity studies, but the etiology and pathogenesis are unknown. However, a nutritional factor is suspected, since minipigs are generally diet restricted. In order to investigate this, newly weaned minipigs were fed different amounts of feed for nine months, after which the bone marrow was evaluated. Serous atrophy was observed in diet-restricted male minipigs fed on a diet based on the nutrient requirements of production pigs, but not in males fed on a diet specially designed for minipigs, at similarly restricted levels. No serous atrophy was observed in females. It was concluded that nutrient requirements of production pigs are not necessarily suitable for minipigs, as a diet based on these nutrient requirements caused total depletion of perirenal fat depots, as well as serous atrophy of the fatty tissue of bone marrow in male Göttingen minipigs at a restricted feeding level.

AB - Serous atrophy of the fatty tissue of bone marrow is occasionally seen in minipigs. It is not associated with compound toxicity, as it has been observed in both dosing and healthy control groups in toxicity studies, but the etiology and pathogenesis are unknown. However, a nutritional factor is suspected, since minipigs are generally diet restricted. In order to investigate this, newly weaned minipigs were fed different amounts of feed for nine months, after which the bone marrow was evaluated. Serous atrophy was observed in diet-restricted male minipigs fed on a diet based on the nutrient requirements of production pigs, but not in males fed on a diet specially designed for minipigs, at similarly restricted levels. No serous atrophy was observed in females. It was concluded that nutrient requirements of production pigs are not necessarily suitable for minipigs, as a diet based on these nutrient requirements caused total depletion of perirenal fat depots, as well as serous atrophy of the fatty tissue of bone marrow in male Göttingen minipigs at a restricted feeding level.

KW - Adipose Tissue/pathology

KW - Animal Feed/analysis

KW - Animals

KW - Atrophy

KW - Body Weight/physiology

KW - Bone Marrow/pathology

KW - Female

KW - Food Deprivation

KW - Male

KW - Sex Factors

KW - Specific Pathogen-Free Organisms

KW - Swine

KW - Swine, Miniature

U2 - 10.1016/j.etp.2006.03.005

DO - 10.1016/j.etp.2006.03.005

M3 - Journal article

C2 - 16713215

VL - 57

SP - 347

EP - 349

JO - Experimental and Toxicologic Pathology

JF - Experimental and Toxicologic Pathology

SN - 0940-2993

IS - 5-6

ER -

ID: 324127870