Repolarization Effects of sertindole manifest as T-wave flatness on the ECG
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Repolarization Effects of sertindole manifest as T-wave flatness on the ECG. / Bhuiyan, Tanveer A.; Graff, Claus; Kanters, Jørgen K.; Nielsen, Jimmi; Struijk, Johannes J.
In: Computing in Cardiology, Vol. 41, 7043059, 01.01.2014, p. 381-384.Research output: Contribution to journal › Conference article › Research › peer-review
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TY - GEN
T1 - Repolarization Effects of sertindole manifest as T-wave flatness on the ECG
AU - Bhuiyan, Tanveer A.
AU - Graff, Claus
AU - Kanters, Jørgen K.
AU - Nielsen, Jimmi
AU - Struijk, Johannes J.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Flattening of the electrocardiographic T-wave has been associated with proarrhythmic risk. It has also been demonstrated that triangulation of the monophasic action potential (MAP) manifests on the ECG as a flattened Twave. In this study we investigate the effects of sertindole on the electrocardiographic T-wave using a recently developed ECG marker of T-wave flatness which is directly correlated with sertindole-induced triangulation of the MAP prior to Torsade de Pointes arrhythmia in dogs. The effect of sertindole on T-wave flatness was compared with the effects of moxifloxacin and placebo on the T-wave. Sertindole caused more flattening of the T-wave compared to moxifloxacin and placebo. Effect sizes also revealed that flattening of the T-wave after sertindole was a more prominent finding compared to QT interval prolongation. An electrocardiographic measurement linking MAP triangulation and T-wave flatness could potentially be used for cardiac safety assessment in drug trials along with other safety measures.
AB - Flattening of the electrocardiographic T-wave has been associated with proarrhythmic risk. It has also been demonstrated that triangulation of the monophasic action potential (MAP) manifests on the ECG as a flattened Twave. In this study we investigate the effects of sertindole on the electrocardiographic T-wave using a recently developed ECG marker of T-wave flatness which is directly correlated with sertindole-induced triangulation of the MAP prior to Torsade de Pointes arrhythmia in dogs. The effect of sertindole on T-wave flatness was compared with the effects of moxifloxacin and placebo on the T-wave. Sertindole caused more flattening of the T-wave compared to moxifloxacin and placebo. Effect sizes also revealed that flattening of the T-wave after sertindole was a more prominent finding compared to QT interval prolongation. An electrocardiographic measurement linking MAP triangulation and T-wave flatness could potentially be used for cardiac safety assessment in drug trials along with other safety measures.
UR - http://www.scopus.com/inward/record.url?scp=84931458196&partnerID=8YFLogxK
M3 - Conference article
AN - SCOPUS:84931458196
VL - 41
SP - 381
EP - 384
JO - Computing in Cardiology
JF - Computing in Cardiology
SN - 0276-6574
M1 - 7043059
T2 - 41st Computing in Cardiology Conference, CinC 2014
Y2 - 7 September 2014 through 10 September 2014
ER -
ID: 204298963