Renal tubular reabsorption of sodium and water during infusion of low-dose dopamine in normal man
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Renal tubular reabsorption of sodium and water during infusion of low-dose dopamine in normal man. / Olsen, Niels Vidiendal; Hansen, J M; Ladefoged, S D; Fogh-Andersen, N; Leyssac, P P.
In: Clinical Science, Vol. 78, No. 5, 05.1990, p. 503-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Renal tubular reabsorption of sodium and water during infusion of low-dose dopamine in normal man
AU - Olsen, Niels Vidiendal
AU - Hansen, J M
AU - Ladefoged, S D
AU - Fogh-Andersen, N
AU - Leyssac, P P
PY - 1990/5
Y1 - 1990/5
N2 - 1. Using the renal clearance of lithium (CLi) as an index of proximal tubular outflow of sodium and water, together with simultaneous measurements of effective renal plasma flow, glomerular filtration rate (GFR) and sodium clearance (CNa), renal function and the tubular segmental reabsorption rates of sodium and water during dopamine infusion (3 micrograms min-1 kg-1) were estimated in 12 normal volunteers. 2. CNa increased by 128% (P less than 0.001). Effective renal plasma flow and GFR increased by 43% (P less than 0.001) and 9% (P less than 0.01), respectively. CLi increased in all subjects by, on average, 44% (P less than 0.001). Fractional proximal reabsorption [1-(CLi/GFR)] decreased by 13% after dopamine infusion (P less than 0.001), and estimated absolute proximal reabsorption rate (GFR-CLi) decreased by 8% (P less than 0.01). Absolute distal sodium reabsorption rate [(CLi-CNa) x PNa, where PNa is plasma sodium concentration] increased (P less than 0.001), and fractional distal sodium reabsorption [(CLi-CNa)/CLi] decreased (P less than 0.001). 3. It is concluded that natriuresis during low-dose dopamine infusion is caused by an increased outflow of sodium from the proximal tubules that is not fully compensated for in the distal tubules.
AB - 1. Using the renal clearance of lithium (CLi) as an index of proximal tubular outflow of sodium and water, together with simultaneous measurements of effective renal plasma flow, glomerular filtration rate (GFR) and sodium clearance (CNa), renal function and the tubular segmental reabsorption rates of sodium and water during dopamine infusion (3 micrograms min-1 kg-1) were estimated in 12 normal volunteers. 2. CNa increased by 128% (P less than 0.001). Effective renal plasma flow and GFR increased by 43% (P less than 0.001) and 9% (P less than 0.01), respectively. CLi increased in all subjects by, on average, 44% (P less than 0.001). Fractional proximal reabsorption [1-(CLi/GFR)] decreased by 13% after dopamine infusion (P less than 0.001), and estimated absolute proximal reabsorption rate (GFR-CLi) decreased by 8% (P less than 0.01). Absolute distal sodium reabsorption rate [(CLi-CNa) x PNa, where PNa is plasma sodium concentration] increased (P less than 0.001), and fractional distal sodium reabsorption [(CLi-CNa)/CLi] decreased (P less than 0.001). 3. It is concluded that natriuresis during low-dose dopamine infusion is caused by an increased outflow of sodium from the proximal tubules that is not fully compensated for in the distal tubules.
KW - Absorption
KW - Adolescent
KW - Adult
KW - Dopamine
KW - Female
KW - Glomerular Filtration Rate
KW - Humans
KW - Kidney
KW - Kidney Tubules
KW - Kidney Tubules, Distal
KW - Kidney Tubules, Proximal
KW - Lithium
KW - Male
KW - Middle Aged
KW - Renal Circulation
KW - Sodium
KW - Water
M3 - Journal article
C2 - 2162278
VL - 78
SP - 503
EP - 507
JO - Clinical Science
JF - Clinical Science
SN - 0143-5221
IS - 5
ER -
ID: 47241017