Regulation of rDNA stability by sumoylation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Regulation of rDNA stability by sumoylation. / Eckert-Boulet, Nadine; Lisby, Michael.

In: DNA Repair, Vol. 8, No. 4, 2009, p. 507-16.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Eckert-Boulet, N & Lisby, M 2009, 'Regulation of rDNA stability by sumoylation', DNA Repair, vol. 8, no. 4, pp. 507-16. https://doi.org/10.1016/j.dnarep.2009.01.015

APA

Eckert-Boulet, N., & Lisby, M. (2009). Regulation of rDNA stability by sumoylation. DNA Repair, 8(4), 507-16. https://doi.org/10.1016/j.dnarep.2009.01.015

Vancouver

Eckert-Boulet N, Lisby M. Regulation of rDNA stability by sumoylation. DNA Repair. 2009;8(4):507-16. https://doi.org/10.1016/j.dnarep.2009.01.015

Author

Eckert-Boulet, Nadine ; Lisby, Michael. / Regulation of rDNA stability by sumoylation. In: DNA Repair. 2009 ; Vol. 8, No. 4. pp. 507-16.

Bibtex

@article{c7f11290f3a211deba73000ea68e967b,
title = "Regulation of rDNA stability by sumoylation",
abstract = "Repair of DNA lesions by homologous recombination relies on the copying of genetic information from an intact homologous sequence. However, many eukaryotic genomes contain repetitive sequences such as the ribosomal gene locus (rDNA), which poses a risk for illegitimate recombination. Therefore, the eukaryotic cell has evolved mechanisms to favor equal sister chromatid exchange (SCE) and suppress unequal SCE, single-strand annealing and break-induced replication. In the budding yeast Saccharomyces cerevisiae, the tight regulation of homologous recombination at the rDNA locus is dependent on the Smc5-Smc6 complex and sumoylation of Rad52, which directs DNA double-strand breaks in the rDNA to relocalize from within the nucleolus to the nucleoplasm before association with the recombination machinery. The relocalization before repair is important for maintaining rDNA stability. The focus of this review is the regulation of recombinational DNA repair at the rDNA locus by sumoylation and the Smc5-Smc6 complex in S. cerevisiae.",
author = "Nadine Eckert-Boulet and Michael Lisby",
note = "Keywords: Cell Cycle Proteins; DNA Damage; DNA Repair; DNA Replication; DNA Sequence, Unstable; DNA, Fungal; DNA, Ribosomal; Rad52 DNA Repair and Recombination Protein; Recombination, Genetic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Small Ubiquitin-Related Modifier Proteins",
year = "2009",
doi = "10.1016/j.dnarep.2009.01.015",
language = "English",
volume = "8",
pages = "507--16",
journal = "DNA Repair",
issn = "1568-7864",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Regulation of rDNA stability by sumoylation

AU - Eckert-Boulet, Nadine

AU - Lisby, Michael

N1 - Keywords: Cell Cycle Proteins; DNA Damage; DNA Repair; DNA Replication; DNA Sequence, Unstable; DNA, Fungal; DNA, Ribosomal; Rad52 DNA Repair and Recombination Protein; Recombination, Genetic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Small Ubiquitin-Related Modifier Proteins

PY - 2009

Y1 - 2009

N2 - Repair of DNA lesions by homologous recombination relies on the copying of genetic information from an intact homologous sequence. However, many eukaryotic genomes contain repetitive sequences such as the ribosomal gene locus (rDNA), which poses a risk for illegitimate recombination. Therefore, the eukaryotic cell has evolved mechanisms to favor equal sister chromatid exchange (SCE) and suppress unequal SCE, single-strand annealing and break-induced replication. In the budding yeast Saccharomyces cerevisiae, the tight regulation of homologous recombination at the rDNA locus is dependent on the Smc5-Smc6 complex and sumoylation of Rad52, which directs DNA double-strand breaks in the rDNA to relocalize from within the nucleolus to the nucleoplasm before association with the recombination machinery. The relocalization before repair is important for maintaining rDNA stability. The focus of this review is the regulation of recombinational DNA repair at the rDNA locus by sumoylation and the Smc5-Smc6 complex in S. cerevisiae.

AB - Repair of DNA lesions by homologous recombination relies on the copying of genetic information from an intact homologous sequence. However, many eukaryotic genomes contain repetitive sequences such as the ribosomal gene locus (rDNA), which poses a risk for illegitimate recombination. Therefore, the eukaryotic cell has evolved mechanisms to favor equal sister chromatid exchange (SCE) and suppress unequal SCE, single-strand annealing and break-induced replication. In the budding yeast Saccharomyces cerevisiae, the tight regulation of homologous recombination at the rDNA locus is dependent on the Smc5-Smc6 complex and sumoylation of Rad52, which directs DNA double-strand breaks in the rDNA to relocalize from within the nucleolus to the nucleoplasm before association with the recombination machinery. The relocalization before repair is important for maintaining rDNA stability. The focus of this review is the regulation of recombinational DNA repair at the rDNA locus by sumoylation and the Smc5-Smc6 complex in S. cerevisiae.

U2 - 10.1016/j.dnarep.2009.01.015

DO - 10.1016/j.dnarep.2009.01.015

M3 - Journal article

C2 - 19261548

VL - 8

SP - 507

EP - 516

JO - DNA Repair

JF - DNA Repair

SN - 1568-7864

IS - 4

ER -

ID: 16586040