Regional cerebral blood flow in chronic alcoholics measured by single photon emission computerized tomography
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Regional cerebral blood flow in chronic alcoholics measured by single photon emission computerized tomography. / Melgaard, B; Henriksen, L; Ahlgren, P; Danielsen, U T; Sørensen, H; Paulson, O B.
In: Acta Neurologica Scandinavica, Vol. 82, No. 2, 08.1990, p. 87-93.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Regional cerebral blood flow in chronic alcoholics measured by single photon emission computerized tomography
AU - Melgaard, B
AU - Henriksen, L
AU - Ahlgren, P
AU - Danielsen, U T
AU - Sørensen, H
AU - Paulson, O B
PY - 1990/8
Y1 - 1990/8
N2 - Regional cerebral blood flow (CBF) was measured by single photon emission computerized tomography of inhaled 133-Xe in 20 chronic alcoholic men. Mean CBF was 51 ml/(100 g x min) compared with 53 ml/(100 g x min) in 20 normals. Reduced cerebellar blood flow correlated both to structural abnormalities seen on CT scan and to cognitive dysfunction. Slight abnormalities of the regional CBF was observed in the alcoholics. They had a higher incidence of regional low flow areas than a control group. Low flow areas were found in frontal and posterior parts of the brain not only in patients with atrophia, but also in patients without CT abnormalities, suggesting neuronal dysfunction. The occurrence of regional low flow areas was associated with the severity of alcoholism, cerebral atrophy and intellectual impairment.
AB - Regional cerebral blood flow (CBF) was measured by single photon emission computerized tomography of inhaled 133-Xe in 20 chronic alcoholic men. Mean CBF was 51 ml/(100 g x min) compared with 53 ml/(100 g x min) in 20 normals. Reduced cerebellar blood flow correlated both to structural abnormalities seen on CT scan and to cognitive dysfunction. Slight abnormalities of the regional CBF was observed in the alcoholics. They had a higher incidence of regional low flow areas than a control group. Low flow areas were found in frontal and posterior parts of the brain not only in patients with atrophia, but also in patients without CT abnormalities, suggesting neuronal dysfunction. The occurrence of regional low flow areas was associated with the severity of alcoholism, cerebral atrophy and intellectual impairment.
KW - Adult
KW - Aged
KW - Alcoholism/diagnostic imaging
KW - Atrophy
KW - Blood Flow Velocity/drug effects
KW - Brain/diagnostic imaging
KW - Cerebrovascular Circulation/drug effects
KW - Ethanol/adverse effects
KW - Humans
KW - Intelligence
KW - Male
KW - Middle Aged
KW - Neurologic Examination
KW - Psychological Tests
KW - Random Allocation
KW - Tomography, Emission-Computed, Single-Photon
KW - Tomography, X-Ray Computed
KW - Xenon Radioisotopes
U2 - 10.1111/j.1600-0404.1990.tb01594.x
DO - 10.1111/j.1600-0404.1990.tb01594.x
M3 - Journal article
C2 - 2256449
VL - 82
SP - 87
EP - 93
JO - Acta Neurologica Scandinavica, Supplement
JF - Acta Neurologica Scandinavica, Supplement
SN - 0065-1427
IS - 2
ER -
ID: 275129318