Reduced Baroreflex Sensitivity in Cluster Headache Patients
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Reduced Baroreflex Sensitivity in Cluster Headache Patients. / Barloese, Mads C J; Mehlsen, Jesper; Brinth, Louise; Lundberg, Helena I S; Jennum, Poul J; Jensen, Rigmor H.
In: Headache, Vol. 55, No. 6, 06.2015, p. 815-24.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Reduced Baroreflex Sensitivity in Cluster Headache Patients
AU - Barloese, Mads C J
AU - Mehlsen, Jesper
AU - Brinth, Louise
AU - Lundberg, Helena I S
AU - Jennum, Poul J
AU - Jensen, Rigmor H
N1 - © 2015 American Headache Society.
PY - 2015/6
Y1 - 2015/6
N2 - OBJECTIVE AND BACKGROUND: Important elements of cluster headache (CH) pathophysiology may be seated in the posterior hypothalamus. Cranial autonomic features are inherent, but involvement of systemic autonomic control is still debated. We aimed to characterize autonomic function as investigated by baroreflex sensitivity (BRS) in CH patients.METHODS: Twenty-six active CH patients and an equal number of age-, sex-, and BMI-matched controls underwent head-up tilt table test and BRS was determined by the sequence method.RESULTS: Compared with controls, patients exhibited a blunted reactivity of RR intervals in response to falls and increases in systolic blood pressure (SBP) (15.3 vs. 20.0 ms/mmHg, P = .0041) in the supine position. Also, compared with controls, BRS was lower in patients having suffered an attack within the past 12 hours (n = 13, 12.5 vs. 22.3 ms/mmHg, P = .0091), opposed to those patients who had not (n = 13, 16.0 ms/mmHg, P = .1523). In the tilted position, the drop in SBP at the carotid sinuses was higher in patients who had recently suffered an attack. Despite this, they exhibited a less marked shortening of RR intervals when compared with patients who had been attack free for longer.CONCLUSIONS: CH patients exhibit a subclinical blunting of BRS that may be affected by the attacks themselves. The fast RR interval fluctuations used in this method reflects cardiovagal responses, thus the blunted responses are suggestive of dysfunction in the parasympathetic division of the autonomic nervous system or in the central relay of impulses from the baroreceptors.
AB - OBJECTIVE AND BACKGROUND: Important elements of cluster headache (CH) pathophysiology may be seated in the posterior hypothalamus. Cranial autonomic features are inherent, but involvement of systemic autonomic control is still debated. We aimed to characterize autonomic function as investigated by baroreflex sensitivity (BRS) in CH patients.METHODS: Twenty-six active CH patients and an equal number of age-, sex-, and BMI-matched controls underwent head-up tilt table test and BRS was determined by the sequence method.RESULTS: Compared with controls, patients exhibited a blunted reactivity of RR intervals in response to falls and increases in systolic blood pressure (SBP) (15.3 vs. 20.0 ms/mmHg, P = .0041) in the supine position. Also, compared with controls, BRS was lower in patients having suffered an attack within the past 12 hours (n = 13, 12.5 vs. 22.3 ms/mmHg, P = .0091), opposed to those patients who had not (n = 13, 16.0 ms/mmHg, P = .1523). In the tilted position, the drop in SBP at the carotid sinuses was higher in patients who had recently suffered an attack. Despite this, they exhibited a less marked shortening of RR intervals when compared with patients who had been attack free for longer.CONCLUSIONS: CH patients exhibit a subclinical blunting of BRS that may be affected by the attacks themselves. The fast RR interval fluctuations used in this method reflects cardiovagal responses, thus the blunted responses are suggestive of dysfunction in the parasympathetic division of the autonomic nervous system or in the central relay of impulses from the baroreceptors.
KW - Adult
KW - Aged
KW - Baroreflex
KW - Blood Pressure
KW - Cluster Headache
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Supine Position
KW - Surveys and Questionnaires
KW - Tilt-Table Test
KW - Young Adult
U2 - 10.1111/head.12586
DO - 10.1111/head.12586
M3 - Journal article
C2 - 26084238
VL - 55
SP - 815
EP - 824
JO - Headache
JF - Headache
SN - 0017-8748
IS - 6
ER -
ID: 161987092