Rapid decline in glomerular filtration rate during the first weeks following heart transplantation
Research output: Contribution to journal › Journal article › Research › peer-review
We hypothesized that a decrease in renal function is seen immediately after heart transplantation (HTX) with little recovery over time. Twelve consecutive patients had their glomerular filtration rate (GFR) measured using (51)Cr-ethylenediaminetetraacetic acid (EDTA) measured GFR (mGFR) before transplantation and at 1, 2, 3, and 26 weeks after transplantation. The mGFR decreased by 28% and 24% during the first 3 and 26 weeks, respectively, with mean blood cyclosporine concentration as an independent risk factor for the decrease in mGFR. The identification of cyclosporine A (CsA) as the most important risk factor for the rapid and sustained decrease in renal function supports the need for more studies on renoprotective strategies immediately after HTX.
Original language | English |
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Journal | Transplantation Proceedings |
Volume | 43 |
Issue number | 5 |
Pages (from-to) | 1904-7 |
Number of pages | 4 |
ISSN | 0041-1345 |
DOIs | |
Publication status | Published - 2011 |
ID: 40151326