Randomized controlled trials: significant results—fragile, though

Research output: Contribution to journal › Comment/debate › Research › peer-review

Standard

Randomized controlled trials : significant results—fragile, though. / Nguyen, Tri Long; Landais, Paul.

In: Kidney International, Vol. 92, No. 6, 2017, p. 1319-1320.

Research output: Contribution to journal › Comment/debate › Research › peer-review

Harvard

Nguyen, TL & Landais, P 2017, 'Randomized controlled trials: significant results—fragile, though', Kidney International, vol. 92, no. 6, pp. 1319-1320. https://doi.org/10.1016/j.kint.2017.06.021

APA

Nguyen, T. L., & Landais, P. (2017). Randomized controlled trials: significant results—fragile, though. Kidney International, 92(6), 1319-1320. https://doi.org/10.1016/j.kint.2017.06.021

Vancouver

Nguyen TL, Landais P. Randomized controlled trials: significant results—fragile, though. Kidney International. 2017;92(6):1319-1320. https://doi.org/10.1016/j.kint.2017.06.021

Author

Nguyen, Tri Long ; Landais, Paul. / Randomized controlled trials : significant results—fragile, though. In: Kidney International. 2017 ; Vol. 92, No. 6. pp. 1319-1320.

Bibtex

@article{9d6c609b98d7426ca4acb409530f5388,
title = "Randomized controlled trials: significant results—fragile, though",
abstract = "In their systematic review, Shochet et al. question the robustness of the statistical significance of the results of randomized controlled trials (RCTs) in nephrology reported in high-impact journals (2005–2014). They hypothesized that a high proportion of RCTs in nephrology would be fragile. They calculated a Fragility Index that is a tool for testing robustness of RCTs, based on 107 RCT reports. The observation of an alarming median Fragility Index equal to 3 suggests that in half of the trials, the sole additional occurrence of 3 events would compromise the significance of nominally significant results.",
author = "Nguyen, {Tri Long} and Paul Landais",
year = "2017",
doi = "10.1016/j.kint.2017.06.021",
language = "English",
volume = "92",
pages = "1319--1320",
journal = "Kidney International. Supplement",
issn = "0098-6577",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Randomized controlled trials

T2 - significant results—fragile, though

AU - Nguyen, Tri Long

AU - Landais, Paul

PY - 2017

Y1 - 2017

N2 - In their systematic review, Shochet et al. question the robustness of the statistical significance of the results of randomized controlled trials (RCTs) in nephrology reported in high-impact journals (2005–2014). They hypothesized that a high proportion of RCTs in nephrology would be fragile. They calculated a Fragility Index that is a tool for testing robustness of RCTs, based on 107 RCT reports. The observation of an alarming median Fragility Index equal to 3 suggests that in half of the trials, the sole additional occurrence of 3 events would compromise the significance of nominally significant results.

AB - In their systematic review, Shochet et al. question the robustness of the statistical significance of the results of randomized controlled trials (RCTs) in nephrology reported in high-impact journals (2005–2014). They hypothesized that a high proportion of RCTs in nephrology would be fragile. They calculated a Fragility Index that is a tool for testing robustness of RCTs, based on 107 RCT reports. The observation of an alarming median Fragility Index equal to 3 suggests that in half of the trials, the sole additional occurrence of 3 events would compromise the significance of nominally significant results.

U2 - 10.1016/j.kint.2017.06.021

DO - 10.1016/j.kint.2017.06.021

M3 - Comment/debate

C2 - 29153136

AN - SCOPUS:85035774141

VL - 92

SP - 1319

EP - 1320

JO - Kidney International. Supplement

JF - Kidney International. Supplement

SN - 0098-6577

IS - 6

ER -

ID: 218396584