Randomized controlled trial on collagen/oxidized regenerated cellulose/silver treatment
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Randomized controlled trial on collagen/oxidized regenerated cellulose/silver treatment. / Gottrup, Finn; Cullen, Breda Mary; Karlsmark, Tonny; Bischoff-Mikkelsen, Morten; Nisbet, Lorraine; Gibson, Molly Camilla.
In: Wound Repair and Regeneration, Vol. 21, No. 2, 27.02.2013, p. 216-225.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Randomized controlled trial on collagen/oxidized regenerated cellulose/silver treatment
AU - Gottrup, Finn
AU - Cullen, Breda Mary
AU - Karlsmark, Tonny
AU - Bischoff-Mikkelsen, Morten
AU - Nisbet, Lorraine
AU - Gibson, Molly Camilla
N1 - © 2013 by the Wound Healing Society.
PY - 2013/2/27
Y1 - 2013/2/27
N2 - Collagen/oxidized regenerated cellulose (ORC)/silver therapy has been designed to facilitate wound healing by normalizing the microenvironment and correcting biochemical imbalances in chronic wounds. The aim of this study was to compare collagen/ORC/silver therapy to control (standard treatment). Patients with diabetic foot ulcers were randomized to either collagen/ORC/silver (24) or control treatment (15). Wound area measurements and wound fluid samples were taken weekly. Protease levels were measured in wound fluid samples to investigate differences between responders (≥50% reduction in wound area by week 4) and nonresponders (<50% reduction in wound area by week 4). There were significantly more responders in the collagen/ORC/silver group compared with the control group (79% vs. 43%, p = 0.035). There were significantly fewer withdrawals from the study because of infection in the collagen/ORC/silver group compared with the control group (0% vs. 31%, p = 0.012). The sum of matrix metalloproteinase-9 and elastase concentration was higher in nonresponders compared with responders at baseline (p = 0.0705) and week 4 (p = 0.012). The results suggest that collagen/ORC/silver normalizes the wound microenvironment and protects against infection, resulting in improved wound healing. It was also demonstrated that measuring a combination of proteases may be a more relevant prognostic healing marker than any individual protease alone.
AB - Collagen/oxidized regenerated cellulose (ORC)/silver therapy has been designed to facilitate wound healing by normalizing the microenvironment and correcting biochemical imbalances in chronic wounds. The aim of this study was to compare collagen/ORC/silver therapy to control (standard treatment). Patients with diabetic foot ulcers were randomized to either collagen/ORC/silver (24) or control treatment (15). Wound area measurements and wound fluid samples were taken weekly. Protease levels were measured in wound fluid samples to investigate differences between responders (≥50% reduction in wound area by week 4) and nonresponders (<50% reduction in wound area by week 4). There were significantly more responders in the collagen/ORC/silver group compared with the control group (79% vs. 43%, p = 0.035). There were significantly fewer withdrawals from the study because of infection in the collagen/ORC/silver group compared with the control group (0% vs. 31%, p = 0.012). The sum of matrix metalloproteinase-9 and elastase concentration was higher in nonresponders compared with responders at baseline (p = 0.0705) and week 4 (p = 0.012). The results suggest that collagen/ORC/silver normalizes the wound microenvironment and protects against infection, resulting in improved wound healing. It was also demonstrated that measuring a combination of proteases may be a more relevant prognostic healing marker than any individual protease alone.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Bandages
KW - Biological Markers
KW - Cellulose, Oxidized
KW - Collagen
KW - Diabetic Foot
KW - Exudates and Transudates
KW - Female
KW - Fibrin Foam
KW - Humans
KW - Inflammation
KW - Male
KW - Matrix Metalloproteinase 1
KW - Matrix Metalloproteinase 9
KW - Middle Aged
KW - Pancreatic Elastase
KW - Silver
KW - Treatment Outcome
KW - Wound Healing
U2 - 10.1111/wrr.12020
DO - 10.1111/wrr.12020
M3 - Journal article
C2 - 23438054
VL - 21
SP - 216
EP - 225
JO - Wound Repair and Regeneration
JF - Wound Repair and Regeneration
SN - 1067-1927
IS - 2
ER -
ID: 138414470