Quantitative studies of lymphoid organs, blood and lymph in inbred athymic and euthymic LEW rats under germfree and specified-pathogen-free conditions
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Quantitative studies of lymphoid organs, blood and lymph in inbred athymic and euthymic LEW rats under germfree and specified-pathogen-free conditions. / Klausen, B; Hougen, H P.
In: Laboratory Animals, Vol. 21, No. 4, 10.1987, p. 342-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Quantitative studies of lymphoid organs, blood and lymph in inbred athymic and euthymic LEW rats under germfree and specified-pathogen-free conditions
AU - Klausen, B
AU - Hougen, H P
PY - 1987/10
Y1 - 1987/10
N2 - Four groups of inbred male LEW rats were examined: A, germfree athymic; B, specified pathogen free (SPF) athymic; C, germfree euthymic; D, SPF euthymic. All animals were killed at 18 weeks and compared with respect to body weight, histological appearance and cell density of the lymphoid organs, haematological values and differential counts of bone marrow, peripheral blood and lymph. Athymic rats had a lower body weight, less densely populated lymphoid organs, and fewer lymphocytes in the blood and lymph compared with euthymic animals. No difference was seen between athymic rats under germfree and SPF conditions, and in general the differences between athymic and euthymic animals were less pronounced under germfree conditions.
AB - Four groups of inbred male LEW rats were examined: A, germfree athymic; B, specified pathogen free (SPF) athymic; C, germfree euthymic; D, SPF euthymic. All animals were killed at 18 weeks and compared with respect to body weight, histological appearance and cell density of the lymphoid organs, haematological values and differential counts of bone marrow, peripheral blood and lymph. Athymic rats had a lower body weight, less densely populated lymphoid organs, and fewer lymphocytes in the blood and lymph compared with euthymic animals. No difference was seen between athymic rats under germfree and SPF conditions, and in general the differences between athymic and euthymic animals were less pronounced under germfree conditions.
KW - Animals
KW - Body Weight
KW - Bone Marrow Cells
KW - Germ-Free Life
KW - Leukocyte Count
KW - Lymph
KW - Lymph Nodes
KW - Lymphocytes
KW - Lymphoid Tissue
KW - Male
KW - Organ Size
KW - Rats
KW - Rats, Inbred Lew
KW - Rats, Inbred Strains
KW - Rats, Mutant Strains
KW - Rats, Nude
KW - Specific Pathogen-Free Organisms
KW - Spleen
KW - Thymus Gland
M3 - Journal article
C2 - 2961927
VL - 21
SP - 342
EP - 347
JO - Laboratory Animals
JF - Laboratory Animals
SN - 0023-6772
IS - 4
ER -
ID: 44516263