Quantitative Electroencephalography Analyzed by Statistical Pattern Recognition as a Diagnostic and Prognostic Tool in Mild Cognitive Impairment: Results from a Nordic Multicenter Cohort Study
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Quantitative Electroencephalography Analyzed by Statistical Pattern Recognition as a Diagnostic and Prognostic Tool in Mild Cognitive Impairment : Results from a Nordic Multicenter Cohort Study. / Schjønning Nielsen, Malene; Simonsen, Anja Hviid; Siersma, Volkert; Engedal, Knut; Jelic, Vesna; Andersen, Birgitte Bo; Naik, Mala; Hasselbalch, Steen Gregers; Høgh, Peter.
In: Dementia and Geriatric Cognitive Disorders. Extra, Vol. 8, No. 3, 2018, p. 426-438.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Quantitative Electroencephalography Analyzed by Statistical Pattern Recognition as a Diagnostic and Prognostic Tool in Mild Cognitive Impairment
T2 - Results from a Nordic Multicenter Cohort Study
AU - Schjønning Nielsen, Malene
AU - Simonsen, Anja Hviid
AU - Siersma, Volkert
AU - Engedal, Knut
AU - Jelic, Vesna
AU - Andersen, Birgitte Bo
AU - Naik, Mala
AU - Hasselbalch, Steen Gregers
AU - Høgh, Peter
PY - 2018
Y1 - 2018
N2 - Aim: To examine diagnostic and prognostic potential of quantitative electroencephalography (qEEG) analyzed by the statistical pattern recognition (SPR) method in patients with cognitive impairment. We compared the differential diagnostic ability of SPR to visual EEG analysis. Correlation between SPR findings and cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers were evaluated. Methods: It is a multicenter cohort study involving 129 patients, (mild cognitive impairment [MCI], AD, and healthy controls). Standardized EEG was performed at baseline. Patients were continuously clinically evaluated. Results: Receiver Operating Characteristic curves showed a low discriminative ability of SPR and no ability to predict clinical progression in patients with MCI. Moderate correlation between SPR analysis and CSF AD biomarkers was found. Conclusion: The diagnostic and prognostic abilities of qEEG were low. The SPR method was superior to the visual EEG analysis. The qEEG method correlates well to CSF AD biomarkers, suggesting association with pathology in AD.
AB - Aim: To examine diagnostic and prognostic potential of quantitative electroencephalography (qEEG) analyzed by the statistical pattern recognition (SPR) method in patients with cognitive impairment. We compared the differential diagnostic ability of SPR to visual EEG analysis. Correlation between SPR findings and cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers were evaluated. Methods: It is a multicenter cohort study involving 129 patients, (mild cognitive impairment [MCI], AD, and healthy controls). Standardized EEG was performed at baseline. Patients were continuously clinically evaluated. Results: Receiver Operating Characteristic curves showed a low discriminative ability of SPR and no ability to predict clinical progression in patients with MCI. Moderate correlation between SPR analysis and CSF AD biomarkers was found. Conclusion: The diagnostic and prognostic abilities of qEEG were low. The SPR method was superior to the visual EEG analysis. The qEEG method correlates well to CSF AD biomarkers, suggesting association with pathology in AD.
KW - Alzheimer disease
KW - Amyloid
KW - Biomarker
KW - Cerebrospinal fluid
KW - Diagnosis
KW - Mild cognitive impairment
KW - Prognosis
KW - Quantitative electroencephalography
KW - Tau protein
U2 - 10.1159/000490788
DO - 10.1159/000490788
M3 - Journal article
C2 - 30631335
AN - SCOPUS:85057758740
VL - 8
SP - 426
EP - 438
JO - Dementia and Geriatric Cognitive Disorders
JF - Dementia and Geriatric Cognitive Disorders
SN - 1420-8008
IS - 3
ER -
ID: 213854793