Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses
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Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses. / Hadrup, Niels; Knudsen, Kristina Bram; Berthing, Trine; Wolff, Henrik; Bengtson, Stefan; Kofoed, Christian; Espersen, Roall; Højgaard, Casper; Winther, Jakob Rahr; Willemoës, Martin; Wedin, Irene; Nuopponen, Markus; Alenius, Harri; Norppa, Hannu; Wallin, Håkan; Vogel, Ulla.
In: Environmental Toxicology and Pharmacology, Vol. 66, 2019, p. 116-125.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses
AU - Hadrup, Niels
AU - Knudsen, Kristina Bram
AU - Berthing, Trine
AU - Wolff, Henrik
AU - Bengtson, Stefan
AU - Kofoed, Christian
AU - Espersen, Roall
AU - Højgaard, Casper
AU - Winther, Jakob Rahr
AU - Willemoës, Martin
AU - Wedin, Irene
AU - Nuopponen, Markus
AU - Alenius, Harri
AU - Norppa, Hannu
AU - Wallin, Håkan
AU - Vogel, Ulla
PY - 2019
Y1 - 2019
N2 - We studied if the pulmonary and systemic toxicity of nanofibrillated celluloses can be reduced by carboxylation. Nanofibrillated celluloses administered at 6 or 18 μg to mice by intratracheal instillation were: 1) FINE NFC, 2–20 μm in length, 2–15 nm in width, 2) AS (−COOH), carboxylated, 0.5–10 μm in length, 4–10 nm in width, containing the biocide BIM MC4901 and 3) BIOCID FINE NFC: as (1) but containing BIM MC4901. FINE NFC administration increased neutrophil influx in BAL and induced SAA3 in plasma. AS (−COOH) produced lower neutrophil influx and systemic SAA3 levels than FINE NFC. Results obtained with BIOCID FINE NFC suggested that BIM MC4901 biocide did not explain the lowered response. Increased DNA damage levels were observed across materials, doses and time points. In conclusion, carboxylation of nanofibrillated cellulose was associated with reduced pulmonary and systemic toxicity, suggesting involvement of OH groups in the inflammatory and acute phase responses.
AB - We studied if the pulmonary and systemic toxicity of nanofibrillated celluloses can be reduced by carboxylation. Nanofibrillated celluloses administered at 6 or 18 μg to mice by intratracheal instillation were: 1) FINE NFC, 2–20 μm in length, 2–15 nm in width, 2) AS (−COOH), carboxylated, 0.5–10 μm in length, 4–10 nm in width, containing the biocide BIM MC4901 and 3) BIOCID FINE NFC: as (1) but containing BIM MC4901. FINE NFC administration increased neutrophil influx in BAL and induced SAA3 in plasma. AS (−COOH) produced lower neutrophil influx and systemic SAA3 levels than FINE NFC. Results obtained with BIOCID FINE NFC suggested that BIM MC4901 biocide did not explain the lowered response. Increased DNA damage levels were observed across materials, doses and time points. In conclusion, carboxylation of nanofibrillated cellulose was associated with reduced pulmonary and systemic toxicity, suggesting involvement of OH groups in the inflammatory and acute phase responses.
KW - Genotoxicity
KW - Nanocellulose
KW - Nanomaterial
KW - Nanoparticle
KW - Neutrophils
KW - Serum amyloid A
U2 - 10.1016/j.etap.2019.01.003
DO - 10.1016/j.etap.2019.01.003
M3 - Journal article
C2 - 30665014
AN - SCOPUS:85060087147
VL - 66
SP - 116
EP - 125
JO - Environmental Toxicology and Pharmacology
JF - Environmental Toxicology and Pharmacology
SN - 1382-6689
ER -
ID: 212858405