Pseudohyperaldosteroism during itraconazole treatment: a hitherto neglected clinically significant side effect

Research output: Contribution to journal › Letter › Research › peer-review

Standard

Pseudohyperaldosteroism during itraconazole treatment : a hitherto neglected clinically significant side effect. / Brandi, Sandra L.; Feltoft, Claus L.; Serup, Jørgen; Eldrup, Ebbe.

In: Drug and Therapeutics Bulletin, Vol. 61, No. 3, 2023, p. 44-47.

Research output: Contribution to journal › Letter › Research › peer-review

Harvard

Brandi, SL, Feltoft, CL, Serup, J & Eldrup, E 2023, 'Pseudohyperaldosteroism during itraconazole treatment: a hitherto neglected clinically significant side effect', Drug and Therapeutics Bulletin, vol. 61, no. 3, pp. 44-47. https://doi.org/10.1136/dtb.2022.243191rep

APA

Brandi, S. L., Feltoft, C. L., Serup, J., & Eldrup, E. (2023). Pseudohyperaldosteroism during itraconazole treatment: a hitherto neglected clinically significant side effect. Drug and Therapeutics Bulletin, 61(3), 44-47. https://doi.org/10.1136/dtb.2022.243191rep

Vancouver

Brandi SL, Feltoft CL, Serup J, Eldrup E. Pseudohyperaldosteroism during itraconazole treatment: a hitherto neglected clinically significant side effect. Drug and Therapeutics Bulletin. 2023;61(3):44-47. https://doi.org/10.1136/dtb.2022.243191rep

Author

Brandi, Sandra L. ; Feltoft, Claus L. ; Serup, Jørgen ; Eldrup, Ebbe. / Pseudohyperaldosteroism during itraconazole treatment : a hitherto neglected clinically significant side effect. In: Drug and Therapeutics Bulletin. 2023 ; Vol. 61, No. 3. pp. 44-47.

Bibtex

@article{feeb8ed9acab493d8b2a8648ed51c92e,
title = "Pseudohyperaldosteroism during itraconazole treatment: a hitherto neglected clinically significant side effect",
abstract = "We describe a married couple who both presented with hypertension and hypokalaemia. Both patients were diagnosed with pseudohyperaldosteronism triggered by the widely used antifungal drug itraconazole. This effect appears to be dose-dependent, where a daily intake of 100 mg itraconazole is enough to induce pseudohyperaldosteronism. Clinicians should be aware of pseudohyperaldosteronism as a possible adverse effect of itraconazole, and we recommend monitoring potassium levels and blood pressure in all patients receiving this drug over a longer period of time. Voriconazole is probably an alternative antifungal treatment to itraconazole but also with this drug potassium levels should be monitored. ",
keywords = "dermatology, drugs: infectious diseases, endocrinology, hypertension, unwanted effects / adverse reactions",
author = "Brandi, {Sandra L.} and Feltoft, {Claus L.} and J{\o}rgen Serup and Ebbe Eldrup",
note = "Funding Information: The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for- profit sectors. Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2023",
doi = "10.1136/dtb.2022.243191rep",
language = "English",
volume = "61",
pages = "44--47",
journal = "Drug and Therapeutics Bulletin",
issn = "0012-6543",
publisher = "B M J Group",
number = "3",

}

RIS

TY - JOUR

T1 - Pseudohyperaldosteroism during itraconazole treatment

T2 - a hitherto neglected clinically significant side effect

AU - Brandi, Sandra L.

AU - Feltoft, Claus L.

AU - Serup, Jørgen

AU - Eldrup, Ebbe

N1 - Funding Information: The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for- profit sectors. Publisher Copyright: © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2023

Y1 - 2023

N2 - We describe a married couple who both presented with hypertension and hypokalaemia. Both patients were diagnosed with pseudohyperaldosteronism triggered by the widely used antifungal drug itraconazole. This effect appears to be dose-dependent, where a daily intake of 100 mg itraconazole is enough to induce pseudohyperaldosteronism. Clinicians should be aware of pseudohyperaldosteronism as a possible adverse effect of itraconazole, and we recommend monitoring potassium levels and blood pressure in all patients receiving this drug over a longer period of time. Voriconazole is probably an alternative antifungal treatment to itraconazole but also with this drug potassium levels should be monitored.

AB - We describe a married couple who both presented with hypertension and hypokalaemia. Both patients were diagnosed with pseudohyperaldosteronism triggered by the widely used antifungal drug itraconazole. This effect appears to be dose-dependent, where a daily intake of 100 mg itraconazole is enough to induce pseudohyperaldosteronism. Clinicians should be aware of pseudohyperaldosteronism as a possible adverse effect of itraconazole, and we recommend monitoring potassium levels and blood pressure in all patients receiving this drug over a longer period of time. Voriconazole is probably an alternative antifungal treatment to itraconazole but also with this drug potassium levels should be monitored.

KW - dermatology

KW - drugs: infectious diseases

KW - endocrinology

KW - hypertension

KW - unwanted effects / adverse reactions

U2 - 10.1136/dtb.2022.243191rep

DO - 10.1136/dtb.2022.243191rep

M3 - Letter

C2 - 36813280

AN - SCOPUS:85138148840

VL - 61

SP - 44

EP - 47

JO - Drug and Therapeutics Bulletin

JF - Drug and Therapeutics Bulletin

SN - 0012-6543

IS - 3

ER -

ID: 396730161