Prospects of Improving Early Ovarian Cancer Diagnosis Using Cervical Cell Swabs
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Prospects of Improving Early Ovarian Cancer Diagnosis Using Cervical Cell Swabs. / Biskup, Edyta; Wils, Regitze Solling; Hogdall, Claus; Hogdall, Estrid.
In: Anticancer Research, Vol. 42, No. 1, 2022, p. 1-12.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Prospects of Improving Early Ovarian Cancer Diagnosis Using Cervical Cell Swabs
AU - Biskup, Edyta
AU - Wils, Regitze Solling
AU - Hogdall, Claus
AU - Hogdall, Estrid
N1 - Publisher Copyright: © 2022 International Institute of Anticancer Research. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Ovarian cancer (OC) has the poorest prognosis and the highest mortality rate among gynecological malignancies, which is largely due to delayed diagnosis. Therefore, an effective detection strategy is a compelling need. Here, we review the potential use of cervical cell swabs (Pap specimens, liquid) for early detection of OC. It has been shown, that malignant cells exfoliate from the ovaries and may be detected in Pap specimens, routinely collected through cervical cancer screening. Using Medical Subject Headings (MeSH) for searching the PubMed database we identified eight studies reporting the use of Pap specimen in early detection of OC. Six focused on detection of gene mutations, using gene panels or analysis of TP53 variants. Two studies reported analysis of methylation profiles. Seven studies were published in 2018 or later. Additionally, we found one study without MeSH terms assigned yet, which postulated using peptide biomarkers present in Pap-test fluid. In this review we present their main findings, discuss challenges this approach presents and include ideas for improved detection.
AB - Ovarian cancer (OC) has the poorest prognosis and the highest mortality rate among gynecological malignancies, which is largely due to delayed diagnosis. Therefore, an effective detection strategy is a compelling need. Here, we review the potential use of cervical cell swabs (Pap specimens, liquid) for early detection of OC. It has been shown, that malignant cells exfoliate from the ovaries and may be detected in Pap specimens, routinely collected through cervical cancer screening. Using Medical Subject Headings (MeSH) for searching the PubMed database we identified eight studies reporting the use of Pap specimen in early detection of OC. Six focused on detection of gene mutations, using gene panels or analysis of TP53 variants. Two studies reported analysis of methylation profiles. Seven studies were published in 2018 or later. Additionally, we found one study without MeSH terms assigned yet, which postulated using peptide biomarkers present in Pap-test fluid. In this review we present their main findings, discuss challenges this approach presents and include ideas for improved detection.
KW - Cervical swab
KW - Liquid Pap specimen
KW - Ovarian cancer
KW - Pap test
KW - Review
U2 - 10.21873/anticanres.15451
DO - 10.21873/anticanres.15451
M3 - Review
C2 - 34969703
AN - SCOPUS:85121987550
VL - 42
SP - 1
EP - 12
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 1
ER -
ID: 317955413